Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease
Open accessAbstract
OBJECTIVE: To examine the efficacy of the immunomodulatory drug fingolimod (FTY720) as a rescue therapy for noninfectious intraocular inflammation. METHODS: Experimental autoimmune uveoretinitis, the murine correlate of human uveitis, was induced in B10.RIII mice. The mice were treated with 2 oral doses of fingolimod daily, either during early ocular infiltration or following clinical onset of the disease. At subsequent times, retinal infiltrates were examined and enumerated using flow cytometry, and structural disease was assessed and scored using histology. RESULTS: Fingolimod treatment, administered 2 days before disease onset, prevented inflammatory cells from infiltrating the retina, with corroborative suppression of histologic disease. A single dose of fingolimod was sufficient in clearing infiltrating leukocytes from the retina within 2 hours of treatment. Furthermore, a single dose of fingolimod administered after disease onset not only abolished retinal infiltrates but also prevented disease relapse for at least 3 weeks. CONCLUSIONS: A short-term, high-dose treatment with fingolimod rapidly reduces ocular infiltrates in experimental autoimmune uveoretinitis, leading to a normal myeloid cell count within the retina. When given at the early stages of intraocular inflammation, fingolimod resolves disease. Clinical Relevance This study directly demonstrates the therapeutic potential of fingolimod and an acute rescue intervention for human noninfectious posterior-segment intraocular inflammatory disease.
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Fingolimod is thought to reduce intraocular inflammation by preventing immune cell migration into the retina.
“Fingolimod is thought to reduce intraocular inflammation by pre venting immune cell migration into the retina (Raveney et al., 2008).”
From Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapy (2025) · cites this paper as Raveney et al., 2008
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- Authors
- Raveney, B. J. E., Copland, D. A., Nicholson, L. B., & Dick, A. D.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- University of Bristol (GB)
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2008-10-01
- Volume
- 126
- Issue
- 10
- Pages
- 1390-1395
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1981233703
- Cited by
- 39
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2021: 1 · 2020: 3 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 7 · 2013: 7 · 2012: 2
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- fingolimod, experimental autoimmune uveoretinitis, uveitis, salvage therapy, immunomodulators, retinal infiltrates, leukocyte infiltration, relapse prevention, posterior segment inflammation, myeloid cells
- MeSH terms
- Fingolimod Hydrochloride, Administration, Oral, Animals, Autoimmune Diseases, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Emergency Treatment, Female, Immunohistochemistry, Immunosuppressive Agents, Mice, Inbred BALB C, Propylene Glycols, Random Allocation, Reference Values, Retinitis, Sensitivity and Specificity, Sphingosine, Uveitis, Treatment Outcome, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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