The DOI matches its Crossref record.
Argon Laser Photocoagulation for Senile Macular Degeneration: Results of a Randomized Clinical Trial
Abstract
The Senile Macular Degeneration Study (SMDS) is a multicenter controlled clinical trial designed to answer the question, "Is argon laser photocoagulation useful in preventing severe visual loss in eyes with evidence of senile macular degeneration and a choroidal neovascular membrane outside the fovea?" Eligible patients were assigned randomly to a "treatment" group or a "no treatment" group. Recruitment in the SMDS has been terminated because, after 18 months of follow-up, 60% of untreated eyes v 25% of treated eyes had experienced severe visual loss. Follow-up of all patients continues to assess long-term results of treatment. Patients with senile macular degeneration who are at risk for the development of choroidal neovascularization should be examined periodically so that if symptomatic neovascularization develops, treatment can be considered before irreversible visual loss occurs.
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“In the 1980s, the Macular Photo-coagulation Study159,160 showed a reduction in vision loss associated with thermal laser photocoagulation, provided the neovascular lesion had well-demarcated (classic) boundaries.”
From Age-related macular degeneration (2008) · cites this paper as [160]
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Neovaskuläre altersabhängige Makuladegeneration
Liegl, R. G.-H. (2025) · Springer Reference Medizin · doi:10.1007/978-3-662-65823-9_51
Gelişken, F., Koçak, N., Wenzel, C. J., Dinçer, K. A., & Wénzel, D. (2025) · Eye · doi:10.1038/s41433-025-04057-w
Viggiano, P., Pignataro, M. G., Termite, A. C., Boscia, G., Savastano, A., Evangelista, F., Alessio, G., Boscia, F., Pető, T., & Chakravarthy, U. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101512
Culham, L. E., Fitzke, F., Timberlake, G. T., et al. (1992) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.1992.tb00398.x
Gerbi, B. J., Lewandowski, L. A., Higgins, P. D., Cho, K. H., Hall, W. A., & Neely, K. A. (1999) · Journal of Radiosurgery · doi:10.1023/a:1022937704355
Soubrane, G., COSCAS, G. J., & Français, C. (1987) · Documenta ophthalmologica. Proceedings series · doi:10.1007/978-94-009-3337-8_36
Argon Laser Treatment: Short and Long Term Results of Randomized Clinical Trials
Bressler, S. B., Bressler, N. M., & Murphy, R. P. (1987) · Documenta ophthalmologica. Proceedings series · doi:10.1007/978-94-009-3337-8_37
Introini, U., Pece, A., Pacelli, G., et al. (1998) · Documenta ophthalmologica. Proceedings series · doi:10.1007/978-94-011-5137-5_65
Metadata
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1982-06-01
- Volume
- 100
- Issue
- 6
- Pages
- 912
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W4243472760
- Cited by
- 405
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 13 · 2013: 5 · 2012: 13
- FWCI
- 25.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- argon laser photocoagulation, senile macular degeneration, choroidal neovascularization, blindness prevention
- MeSH terms
- Aged, Clinical Trials as Topic, Fluorescein Angiography, Follow-Up Studies, Humans, Lasers, Macular Degeneration, Middle Aged, Random Allocation, Vision Disorders, Laser Therapy
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