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Platelet-Derived Growth Factor Is Chemotactic for Human Retinal Pigment Epithelial Cells
Abstract
The presence of blood or serum in the vitreous cavity has been associated with the formation of cellular membranes in proliferative vitreoretinopathy and after penetrating ocular trauma. Retinal pigment epithelial (RPE) cells are an important component of these membranes. For RPE cells to effectively spread throughout the vitreous cavity and form contractile membranes, cell migration must occur. Serum has been shown to initiate RPE cell migration. Fibronectin (FN), a glycoprotein found in serum, stimulates RPE cell migration but accounts for only part of the stimulatory effect of serum. We report that another serum component, platelet-derived growth factor (PDGF), also stimulates RPE cell migration. Furthermore, the effect of PDGF and FN are additive and together probably account for a large part of the chemotactic activity found in serum.
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Citations
Cited by
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Microvascular complications and diabetic retinopathy: recent advances and future implications
Barot, M., Gokulgandhi, M. R., Patel, S., & Mitra, A. K. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.12.206 · Cited by 92
Metadata
- Authors
- Campochiaro, P. A., & Glaser, B. M.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1985-04-01
- Volume
- 103
- Issue
- 4
- Pages
- 576-579
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1981970388
- Cited by
- 170
- References
- 0
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Platelet-Derived Growth Factor Is Chemotactic for Human Retinal Pigment Epithelial Cells. https://app.cochat.ai/papers/10.1001/archopht.1985.01050040118034
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- Campochiaro, P. A., & Glaser, B. M. (1985). Platelet-Derived Growth Factor Is Chemotactic for Human Retinal Pigment Epithelial Cells. Archives of Ophthalmology. https://doi.org/10.1001/archopht.1985.01050040118034
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