Microvascular complications and diabetic retinopathy: recent advances and future implications
Open accessAbstract
Retinal microvascular alterations have been observed during diabetic retinopathy (DR) due to the retinal susceptibility towards subtle pathological alterations. Therefore, retinal microvascular pathology is essential to understand the nature of retinal degenerations during DR. In this review, the role of retinal microvasculature complications during progression of DR, along with recent efforts to normalize such alterations for better therapeutic outcome, will be underlined. In addition, current therapeutics and future directions for advancement of standard treatment for DR patients will be discussed.
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Neovascularization is the predominant pathology in various blinding disorders including wet AMD, ME and proliferative DR.
“Neovascularization is the predominant pathology in various blinding disorders including wet age-related macular degeneration (AMD), macular edema (ME) and proliferative diabetic retinopathy (DR) [164].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [164]
The Abstract (page unavailable) defines proliferative diabetic retinopathy by the growth of abnormal new blood vessels, and the Anti-VEGF therapy section discusses neovascular AMD. But the paper lists macular edema and neovascularization as separate abnormalities and does not establish neovascularization as the predominant pathology of macular edema. (LLM, conf=0.87)
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From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
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“Neovascularization is the predominant pathology in various blinding disorders including wet age-related macular degeneration (AMD), macular edema (ME) and proliferative diabetic retinopathy (DR) [164].”
- Authors
- Barot, M., Gokulgandhi, M. R., Patel, S., & Mitra, A. K.
- Affiliations
- University of Missouri–Kansas City (US)
- ORCID
- Patel, Sulabh
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2013-03
- Volume
- 5
- Issue
- 3
- Pages
- 301-314
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- PMC
- PMC3840430
- OpenAlex
- W2158855079
- Cited by
- 92
- References
- 137
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 12 · 2023: 3 · 2022: 16 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 2
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Future Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (RO1 EY 09171–16 and RO1 EY 10659–14)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- diabetic retinopathy, retinal microvasculature, microvascular complications, retinal degeneration, diabetic retinopathy progression
- MeSH terms
- Animals, Antioxidants, Diabetic Retinopathy, Humans, Mitochondria, Retina, Retinal Vessels, Steroids, Vascular Endothelial Growth Factor A, Protein Kinase Inhibitors, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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