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Sustained-Release Ganciclovir Therapy for Treatment of Cytomegalovirus Retinitis: Use of an Intravitreal Device
Abstract
A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (CMV) retinitis were recruited as part of a phase 1 study. Thirteen eyes with active CMV retinitis underwent surgical implantation of the ganciclovir device. All eyes showed resolution of the CMV retinitis; none showed progression. Visual acuity remained unchanged in three eyes, improved in six eyes, and decreased in four eyes. Surgical complications included mild vitreous hemorrhage, astigmatism, and suprachoroidal placement of the device. Retinal detachment occurred in three eyes as the retinitis resolved. This new intraocular drug delivery system offers many advantages compared with intravenous therapy or repeated intravitreal ganciclovir injections for the management of CMV retinitis in patients with AIDS.
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Cited by
Campochiaro, P. A., Brown, D. M., Pearson, A., Ciulla, T., Boyer, D., Holz, F. G., Tolentino, M., Gupta, A., Duarte, L., Madreperla, S., et al. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2010.12.028 · Cited by 405
Martin, D. F. (1994) · Archives of Ophthalmology · doi:10.1001/archopht.1994.01090240037023 · Cited by 338
Ocular Preparations: The Formulation Approach
Pal Kaur, I., & Kanwar, M. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120003445 · Cited by 310
Treatment of Cytomegalovirus Retinitis with a Sustained-Release Ganciclovir Implant
Musch, D. C., Martin, D. F., Gordon, J. F., Davis, M. D., & Kuppermann, B. D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370203 · Cited by 286
INTRAVITREAL INJECTION OF THERAPEUTIC AGENTS
PEYMAN, G. A., LAD, E. M., & MOSHFEGHI, D. M. (2009) · Retina · doi:10.1097/iae.0b013e3181a94f01 · Cited by 255
Metadata
- Authors
- Sanborn, G. E.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1992-02-01
- Volume
- 110
- Issue
- 2
- Pages
- 188
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1993433202
- Cited by
- 230
- References
- 0
- FWCI
- 24.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sanborn, G. E. (1992). Sustained-Release Ganciclovir Therapy for Treatment of Cytomegalovirus Retinitis: Use of an Intravitreal Device. Archives of Ophthalmology. https://doi.org/10.1001/archopht.1992.01080140044023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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