The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Treatment of Cytomegalovirus Retinitis With an Intraocular Sustained-Release Ganciclovir Implant: A Randomized Controlled Clinical Trial
Abstract
BACKGROUND AND METHODS: We performed a randomized controlled clinical trial to assess the safety and efficacy of a 1 microgram/h ganciclovir implant for the treatment of newly diagnosed cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS). Patients with previously untreated peripheral CMV retinitis were randomly assigned either to immediate treatment with the ganciclovir implant or to deferred treatment. Standardized fundus photographs were taken at 2-week intervals and analyzed in a masked fashion. The study end point was progression of retinitis based on the photographic assessment. RESULTS: Twenty-six patients (30 eyes) were enrolled. The median time to progression of retinitis was 15 days in the deferred treatment group (n = 16) vs 226 days in the immediate treatment group (n = 14) (P < .00001, log-rank test). During the study, 39 primary implants and 12 exchange implants were placed in immediate-treatment eyes, deferred-treatment eyes that progressed, or contralateral eyes that developed CMV retinitis. Postoperative complications in the total series included seven late retinal detachments and one retinal tear without detachment. Final visual acuity was 20/25 or better in 34 of 39 eyes. The estimated risk of developing CMV retinitis in the fellow eye was 50% at 6 months. Biopsy-proven visceral CMV disease developed in eight (31%) of 26 patients. The median survival was 295 days. CONCLUSION: The ganciclovir implant is effective for the treatment of CMV retinitis. Patients with unilateral CMV retinitis treated with the implant are likely to develop CMV retinitis in the fellow eye, and some patients will develop visceral CMV disease.
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Cites
New Visual Acuity Charts for Clinical Research
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Acquired Immune Deficiency Syndrome
Holland, G. N., Pepose, J. S., Pettit, T. H., Gottlieb, M. S., Yee, R. D., & Foos, R. Y. (1983) · Ophthalmology · doi:10.1016/s0161-6420(83)80009-8 · Cited by 840
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Clinical Manifestations of AIDS in the Era of Pneumocystis Prophylaxis
Hoover, D. R., Saah, A. J., Bacellar, H., Phair, J., Detels, R., Anderson, R., & Kaslow, R. A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312233292604 · Cited by 406
Cytomegalovirus Retinitis and Acquired Immunodeficiency Syndrome
Jabs, D. A. (1989) · Archives of Ophthalmology · doi:10.1001/archopht.1989.01070010077031 · Cited by 379
Palestine, A. G., Polis, M. A., De Smet, M. D., Baird, B. F., Falloon, J., Kovacs, J. A., Davey, R. T., Zurlo, J. J., Zunich, K. M., Davis, M., et al. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-9-665 · Cited by 327
Sanborn, G. E. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080140044023 · Cited by 230
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Henry, K., Cantrill, H., Fletcher, C., Chinnock, B. J., & Balfour, H. H. (1987) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(14)74163-7 · Cited by 196
Cited by
Oral Ganciclovir for Patients with Cytomegalovirus Retinitis Treated with a Ganciclovir Implant
Martin, D. F., Kuppermann, B. D., Wolitz, R. A., Palestine, A. G., Li, H., & Robinson, C. A. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904083401402 · Cited by 485
Self-citationCrumpacker, C. S. (1996) · New England Journal of Medicine · doi:10.1056/nejm199609053351007 · Cited by 382
Treatment of Cytomegalovirus Retinitis with a Sustained-Release Ganciclovir Implant
Musch, D. C., Martin, D. F., Gordon, J. F., Davis, M. D., & Kuppermann, B. D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370203 · Cited by 286
Self-citationINTRAVITREAL INJECTION OF THERAPEUTIC AGENTS
PEYMAN, G. A., LAD, E. M., & MOSHFEGHI, D. M. (2009) · Retina · doi:10.1097/iae.0b013e3181a94f01 · Cited by 255
Cannulation of the suprachoroidal space: a novel drug delivery methodology to the posterior segment
Olsen, T. W., Feng, X., Wabner, K., Conston, S. R., Sierra, D. H., Folden, D. V., Smith, M. E., & Cameron, J. D. (2006) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.05.045 · Cited by 171
Metadata
- Authors
- Martin, D. F.
- Venue
- Archives of Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 1994-12-01
- Volume
- 112
- Issue
- 12
- Pages
- 1531
- ISSN
- 0003-9950 (ISSN-L)
- OpenAlex
- W1965146541
- Cited by
- 338
- References
- 16
- FWCI
- 27.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Treatment of Cytomegalovirus Retinitis With an Intraocular Sustained-Release Ganciclovir Implant: A Randomized Controlled Clinical Trial. https://app.cochat.ai/papers/10.1001/archopht.1994.01090240037023
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- Martin, D. F. (1994). Treatment of Cytomegalovirus Retinitis With an Intraocular Sustained-Release Ganciclovir Implant: A Randomized Controlled Clinical Trial. Archives of Ophthalmology. https://doi.org/10.1001/archopht.1994.01090240037023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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