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Cited by 290

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Long-term Quality of Life After Treatment of Laryngeal Cancer

Terrell, Jeffrey E., Fisher, Susan G., Wolf, Gregory T.·1998·Archives of Otolaryngology–Head & Neck Surgery

Abstract

OBJECTIVE: To assess long-term quality of life in surviving patients with advanced laryngeal cancer. DESIGN: A follow-up long-term quality-of-life survey of patients randomized to the Veterans Affairs Laryngeal Cancer Study No. 268 on induction chemotherapy and radiation (CT + RT) vs surgery and RT. SETTING AND PATIENTS: Forty-six (71%) of the 65 surviving patients with prior stage III or IV laryngeal cancer who could be contacted completed the survey: 25 from the surgery and RT group and 21 from the CT + RT group. Baseline demographic and clinical characteristics among survey respondents were similar, except that those in the CT + RT group were significantly older (mean, 61.2 years) than those in the surgery and RT group (mean, 55.7 years; P<.05). INTERVENTIONS AND MAIN OUTCOME MEASURES: Patients completed the University of Michigan Head and Neck Quality of Life (HNQOL) instrument, the Medical Outcomes Studies Short-Form 36 (SF-36) general health survey, the Beck Depression Inventory as well as smoking and alcohol consumption surveys. RESULTS: Patients randomized to the CT + RT group had significantly better (P<.05) quality-of-life scores on the SF-36 mental health domain (76.0) than the surgery and RT group (63.0), and also had better HNQOL pain scores (81.3 vs 64.3). Compared with patients who underwent laryngectomy, patients with intact larynges (CT + RT with larynx) had significantly less bodily pain (88.5 vs 56.5), better scores on the SF-36 mental health (79.8 vs 64.7), and better HNQOL emotion (89.7 vs 79.4) scores. More patients in the surgery and RT group (28%) were depressed than in the CT + RT group (15%). CONCLUSION: Better quality-of-life scores in the CT + RT groups appear to be related to more freedom from pain, better emotional well-being, and lower levels of depression than to preservation of speech function.

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Metadata

Authors
Terrell, J. E., Fisher, S. G., & Wolf, G. T.
Venue
Archives of Otolaryngology–Head & Neck Surgery
Published
1998-09-01
Volume
124
Issue
9
Pages
964
ISSN
0886-4470 (ISSN-L)
OpenAlex
W2000219306
Cited by
290
References
13
FWCI
11.16
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Long-term Quality of Life After Treatment of Laryngeal Cancer. https://app.cochat.ai/papers/10.1001/archotol.124.9.964
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Terrell, J. E., Fisher, S. G., & Wolf, G. T. (1998). Long-term Quality of Life After Treatment of Laryngeal Cancer. Archives of Otolaryngology–Head & Neck Surgery. https://doi.org/10.1001/archotol.124.9.964

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