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Merkel Cell Carcinoma (Endocrine Carcinoma of the Skin) of the Head and Neck
Abstract
Merkel cell carcinoma, also known as endocrine carcinoma of the skin, is a recently recognized and particularly aggressive form of skin cancer that exhibits histologic features similar to those of endocrine malignant neoplasms arising from other tissues. Forty-one patients with Merkel cell carcinoma arising from the cutaneous surfaces of the head and neck were seen at the University of Texas M. D. Anderson Hospital, Houston, between 1966 and 1983. Regional lymph node metastasis occur early and frequently, with a 79% overall incidence observed during the course of the disease. Treatment should consist of a wide resection of the primary tumor. A regional lymphadenectomy, when feasible, is successful in controlling nodal metastases. Postoperative radiation is recommended as an important adjuvant.
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Citations
Cited by
Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features
Heath, M., Jaimes, N., Lemos, B., Mostaghimi, A., Wang, L. C., Peñas, P. F., & Nghiem, P. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.11.020 · Cited by 934
Neuroendocrine (Merkel Cell) Carcinoma of the Skin: Its Natural History, Diagnosis, and Treatment
HITCHCOCK, C. L., BLAND, K. I., LANEY, R. G., FRANZINI, D., HARRIS, B., & COPELAND, E. M. (1988) · Annals of Surgery · doi:10.1097/00000658-198802000-00015 · Cited by 484
Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology
Bichakjian, C. K., Olencki, T., Aasi, S. Z., Alam, M., Andersen, J. S., Blitzblau, R., Bowen, G. M., Contreras, C. M., Daniels, G. A., Decker, R., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0055 · Cited by 319
Merkel cell carcinoma: an updated review focused on bone and bone marrow metastases
Scotti, B., Broseghini, E., Ricci, C., Corti, B., Viola, C., Misciali, C., Baraldi, C., Vaccari, S., Lambertini, M., Venturi, F., et al. (2025) · Cancers · doi:10.3390/cancers17132253 · Cited by 9
Metadata
- Authors
- Goepfert, H., Remmler, D., Silva, E., & Wheeler, B.
- Venue
- Archives of Otolaryngology - Head and Neck Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1984-11-01
- Volume
- 110
- Issue
- 11
- Pages
- 707-712
- ISSN
- 0886-4470 (ISSN-L)
- OpenAlex
- W2145048826
- Cited by
- 203
- References
- 0
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Merkel Cell Carcinoma (Endocrine Carcinoma of the Skin) of the Head and Neck. https://app.cochat.ai/papers/10.1001/archotol.1984.00800370009002
- The paper
- Goepfert, H., Remmler, D., Silva, E., & Wheeler, B. (1984). Merkel Cell Carcinoma (Endocrine Carcinoma of the Skin) of the Head and Neck. Archives of Otolaryngology - Head and Neck Surgery. https://doi.org/10.1001/archotol.1984.00800370009002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
