The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Neuroendocrine (Merkel Cell) Carcinoma of the Skin: Its Natural History, Diagnosis, and Treatment
Open accessAbstract
Over 400 cases of neuroendocrine (Merkel cell) carcinoma of the skin (NCS) have been reported. This tumor continues to pose problems in diagnosis and effective treatment for physicians unfamiliar with its biological characteristics. Reported here are five additional cases of NCS and the literature for this rare neoplasm is comprehensively reviewed. An early and accurate diagnosis is made possible by combining clinical presentation with results of histologic study, immunoperoxidase staining for neuron-specific enolase (NSE), epithelial membrane antigen (EMA), cytokeratins, and electron microscopy. NCS is an aggressive tumor. Depending on the length of follow-up, up to 40% of tumors locally recur, 55% develop regional nodal metastases, and 36% undergo distant metastasis. Survival is sex, but not age, dependent, with an overall 2-year survival rate of 72% (males 58% vs. females 79%). No standard procedure for initial and/or follow-up treatment for NCS exists. The authors recommend that NCS be treated, whenever possible, using the same rationale as applied for the treatment of squamous cell carcinoma of the skin.
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Citations
Cites
Trabecular Carcinoma of the Skin
Toker, C. (1972) · Archives of Dermatology · doi:10.1001/archderm.1972.01620040075020 · Cited by 1,350
The Use of Antiavidin Antibody and Avidin-Biotin-Peroxidase Complex in Immunoperoxidase Technics
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Trabecular carcinoma of the skin. An ultrastructural study
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Merkel Cell Carcinoma (Endocrine Carcinoma of the Skin) of the Head and Neck
Goepfert, H., Remmler, D., Silva, E., & Wheeler, B. (1984) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1984.00800370009002 · Cited by 203
THE MERKEL CELL SYSTEM AND A COMPARISON BETWEEN IT AND THE NEUROSECRETORY OR APUD CELL SYSTEM
WINKELMANN, R. K. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12497864 · Cited by 144
Neuroendocrine (Merkel Cell) Carcinomas of the Skin: An Ultrastructural Study of Nine Cases
Silva, E., & Mackay, B. (1981) · Ultrastructural Pathology · doi:10.3109/01913128109031497 · Cited by 67
Cited by
Tai, P. T. H., Yu, E., Winquist, E., Hammond, A., Stitt, L., Tonita, J., & Gilchrist, J. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.12.2493 · Cited by 351
Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology
Bichakjian, C. K., Olencki, T., Aasi, S. Z., Alam, M., Andersen, J. S., Blitzblau, R., Bowen, G. M., Contreras, C. M., Daniels, G. A., Decker, R., et al. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2018.0055 · Cited by 319
Chemotherapy for patients with locally advanced or metastatic Merkel cell carcinoma
Voog, E., Biron, P., Martin, J.-P., & Blay, J.-Y. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990615)85:12<2589::aid-cncr15>3.0.co;2-f · Cited by 301
Segal, N. H., He, A. R., Doi, T., Levy, R., Bhatia, S., Pishvaian, M. J., Cesari, R., Chen, Y., Davis, C. B., Huang, B., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1922 · Cited by 267
Metadata
- Authors
- HITCHCOCK, C. L., BLAND, K. I., LANEY, R. G., FRANZINI, D., HARRIS, B., & COPELAND, E. M.
- Venue
- Annals of Surgery
- Published
- 1988-02
- Volume
- 207
- Issue
- 2
- Pages
- 201-207
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W1989608434
- Cited by
- 484
- References
- 7
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Neuroendocrine (Merkel Cell) Carcinoma of the Skin: Its Natural History, Diagnosis, and Treatment. https://app.cochat.ai/papers/10.1097/00000658-198802000-00015
- The paper
- HITCHCOCK, C. L., BLAND, K. I., LANEY, R. G., FRANZINI, D., HARRIS, B., & COPELAND, E. M. (1988). Neuroendocrine (Merkel Cell) Carcinoma of the Skin: Its Natural History, Diagnosis, and Treatment. Annals of Surgery. https://doi.org/10.1097/00000658-198802000-00015
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
