Clinical Evaluation of a New Measles-Mumps-Rubella Trivalent Vaccine
Abstract
In a series of clinical studies of a combined measles (Schwarz strain), mumps (Jeryl Lynn strain), and rubella (Cendehill strain) vaccine, 1,481 children received the vaccine or a placebo. The vaccine did not cause any significant reactions. The frequencies of mild, transient fever or rash or both in triple-susceptible vaccinees were similar to those that follow use of Schwarz strain measles vaccine alone. Measles, mumps, and rubella seroconversion rates in triple-susceptible vaccinees ranged from 95% to 100%. Geometric mean antibody titers were as high as those that usually result from use of these same virus strains as monovalent vaccines.
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In the two trials assessed as being at high risk of reporting bias (Bloom 1975; Schwarz 1975), adverse effects were reported for only 60% and 39% of participants, respectively.
“In the two trials we assessed as being at high risk of reporting bias (Bloom 1975; Schwarz 1975), we reported adverse effects for only 60% and 39% of participants, respectively.”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Schwarz 1975
In Bloom 1975 and Schwarz 1975, the risk of reporting bias was high.
“In the two trials we assessed as being at high risk of reporting bias (Bloom 1975; Schwarz 1975)”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Schwarz 1975
Bloom 1975 and Schwarz 1975 concluded that the incidence of raised temperature, rash, lymphadenopathy, coryza, rhinitis, cough, local reactions or limb and joint symptoms were not significantly different from placebo.
“The trials by Bloom and Schwarz concluded that the incidence of raised temperature, rash, lymphadenopathy, coryza, rhinitis, cough, local reactions or limb and joint symptoms were not significantly different from placebo (Bloom 1975; Schwarz 1975).”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Schwarz 1975
Cited by
Sorted by citations
Vaccines for measles, mumps and rubella in children
Demicheli, V., Rivetti, A., Debalini, M. G., & Di Pietrantonj, C. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004407.pub3 · Cited by 372 · see citing works
Benefits, risks and costs of immunization for measles, mumps and rubella.
White, C. C., Koplan, J. P., & Orenstein, W. A. (1985) · American Journal of Public Health · doi:10.2105/ajph.75.7.739 · Cited by 193 · see citing works
Serological evaluation of a measles, mumps, and rubella vaccine
Robertson, C. M., Bennett, V. J., Jefferson, N., & Mayon-White, R. T. (1988) · Archives of Disease in Childhood · doi:10.1136/adc.63.6.612 · Cited by 34 · see citing works
- Authors
- Schwarz, A. J. F.
- Corresponding author
- Schwarz, Anton J. F.
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1975-12-01
- Volume
- 129
- Issue
- 12
- Pages
- 1408
- ISSN
- 1072-4710 (ISSN-L)
- OpenAlex
- W2009286117
- Cited by
- 27
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Keywords
- MMR vaccine, vaccine safety, vaccine adverse reactions, seroconversion, antibody titers, children
- MeSH terms
- Antibodies, Viral, Antibody Formation, Child, Child, Preschool, Drug Eruptions, Drug Evaluation, Drug Therapy, Combination, Female, Fever, Humans, Immunization, Infant, Male, Measles Vaccine, Mumps Vaccine, Placebos, Rubella Vaccine
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