Serological evaluation of a measles, mumps, and rubella vaccine
Open accessAbstract
Combined measles, mumps, and rubella vaccination is soon to become available in Britain in the routine immunisation programme. A controlled study was performed in 319 children, aged 13 months, to assess the antibody response and clinical reactions to a new combined measles, mumps, and rubella vaccine in comparison with a single component measles vaccine. In the children who received the combined vaccine, seroconversion was established in 93% for measles, 99% for rubella, and 100% for mumps. In the children who received the single measles vaccine, seroconversion was established in 92% for measles and in none for rubella and mumps. There was no increase in clinical reactions after the measles, mumps, and rubella vaccine compared with the measles vaccine. These results suggest that this combined vaccine would be effective and safe in a British population and give further support for the introduction of the combined measles, mumps, and rubella vaccine to Britain.
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In Miller 1989 and Robertson 1988, symptoms were similar following MMR and measles vaccination except for a higher incidence of parotitis following MMR vaccination.
“Two studies (Miller 1989; Robertson 1988) found that symptoms were similar following MMR and measles vaccination except for a higher incidence of parotitis following MMR vaccination (Miller 1989).”
From Vaccines for measles, mumps and rubella in children (2012) · cites this paper as Robertson 1988
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Cites
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Vaccines for measles, mumps and rubella in children
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- Authors
- Robertson, C. M., Bennett, V. J., Jefferson, N., & Mayon-White, R. T.
- ORCID
- Robertson, C M
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1988-06-01
- Volume
- 63
- Issue
- 6
- Pages
- 612-616
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- PMC
- PMC1778844
- OpenAlex
- W2107281954
- Cited by
- 34
- References
- 12
- Citations by year
- 2021: 1 · 2020: 1 · 2013: 2 · 2012: 2
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Disease in Childhood (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- MMR vaccine, combined vaccine, measles vaccine, seroconversion, antibody response, vaccine safety, children, vaccine introduction
- MeSH terms
- Antibodies, Viral, Clinical Trials as Topic, Drug Combinations, Female, Humans, Infant, Male, Measles, Measles Vaccine, Mumps, Mumps Vaccine, Rubella, Rubella Vaccine, Measles-Mumps-Rubella Vaccine
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