Detection of Interleukin 1β but Not Tumor Necrosis Factor—α in Cerebrospinal Fluid of Children With Aseptic Meningitis
Abstract
Tumor necrosis factor-alpha and interleukin 1 beta have been shown to be mediators of meningeal inflammation in animal models of bacterial meningitis. The presence of both cytokines in cerebrospinal fluid (CSF) of patients with bacterial meningitis has been documented recently. In this study, we measured concentrations of interleukin 1 beta and tumor necrosis factor-alpha in CSF samples from 36 patients with nonbacterial (aseptic) meningitis, 13 of whom had culture-proved enteroviral meningitis, and from 14 control patients. None of the samples from patients with aseptic meningitis and from the controls had detectable tumor necrosis factor activity in CSF. Thirty-two (89%) of 36 patients with aseptic meningitis had detectable interleukin 1 beta in CSF (mean +/- SEM, 48 +/- 11 pg/mL). These concentrations were significantly smaller than those previously reported in patients with bacterial meningitis (944 +/- 128 pg/mL). Only 2 of the 14 control patients had detectable CSF interleukin 1 beta concentrations of 21 and 42 pg/mL. A significant correlation was evident between interleukin-1 beta concentrations and white blood cell counts in the CSF of patients with aseptic meningitis. Our data suggest that the initial events of CSF inflammation in children with aseptic meningitis are different than those in patients with bacterial meningitis, and the participation of these two cytokines, especially tumor necrosis factor-alpha, is less critical to the process.
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Increased levels of IL-1β, a pro-inflammatory cytokine, were found in patients with aseptic meningitis.
“Another study showed an increased level of IL-1β (a pro-inflammatory cytokine) in patients with aseptic meningitis [51].”
From Viral meningitis: an overview (2021) · cites this paper as [51]
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- Authors
- Ramilo, O.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Ramilo, Octavio
- ORCID
- Ramilo, Octavio
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 1990-03-01
- Volume
- 144
- Issue
- 3
- Pages
- 349
- ISSN
- 1072-4710 (ISSN-L)
- OpenAlex
- W2093105173
- Cited by
- 51
- References
- 17
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01hd022766-02)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (5 PO1 HD22766-03)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- IL-1β, TNF-α, aseptic meningitis, cerebrospinal fluid cytokines, enteroviral meningitis, bacterial meningitis, meningeal inflammation, CSF white blood cell count, children
- MeSH terms
- Adolescent, Child, Child, Preschool, Humans, Infant, Interleukin-1, Meningitis, Meningitis, Aseptic, Tumor Necrosis Factor-alpha
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