Attenuation of the Effect of the FTO rs9939609 Polymorphism on Total and Central Body Fat by Physical Activity in Adolescents: The HELENA Study
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OBJECTIVE: To examine whether physical activity attenuates the effect of the FTO rs9939609 polymorphism on body fat estimates in adolescents. DESIGN: Cross-sectional study. SETTING: Athens, Greece; Dortmund, Germany; Ghent, Belgium; Heraklion, Greece; Lille, France; Pécs, Hungary; Rome, Italy; Stockholm, Sweden; Vienna, Austria; and Zaragoza, Spain, from October 2006 to December 2007. PARTICIPANTS: Adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (n = 752). MAIN EXPOSURE: Physical activity. MAIN OUTCOME MEASURES: The FTO rs9939609 polymorphism was genotyped. Physical activity was assessed by accelerometry. We measured weight, height, waist circumference, and triceps and subscapular skinfolds; body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]) and body fat percentage were calculated. RESULTS: The A allele of the FTO polymorphism was significantly associated with higher BMI (+0.42 per risk allele), higher body fat percentage (+1.03% per risk allele), and higher waist circumference (+0.85 cm per risk allele). We detected significant or borderline gene x physical activity interactions for the studied body fat estimates (for interaction, P = .02, .06, and .10 for BMI, body fat percentage, and waist circumference, respectively). Indeed, the effect of the FTO rs9939609 polymorphism on these body fat parameters was much lower in adolescents who met the daily physical activity recommendations (ie, >/=60 min/d of moderate to vigorous physical activity) compared with those who did not: +0.17 vs +0.65 per risk allele in BMI, respectively; +0.40% vs +1.70% per risk allele in body fat percentage, respectively; and +0.60 vs +1.15 cm per risk allele in waist circumference, respectively. CONCLUSION: Adolescents meeting the daily physical activity recommendations may overcome the effect of the FTO rs9939609 polymorphism on obesity-related traits.
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Adolescents meeting daily physical activity recommendations overcame the effect of the FTO rs9939609 AA polymorphism on obesity-related BMI, body fat, and waist circumference traits seen in sedentary subjects.
“Adolescents meeting the daily physical activity recommendations overcame the effect of the FTO rs9939609 AA polymorphism on obesity-related BMI, body fat, and waist circumference traits seen in sedentary subjects (450).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [450]
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References 31 · Cited by 114
- Authors
- Ruiz, J. R.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Ruiz, Jonatan R.
- ORCID
- Ruiz, Jonatan R.
- Venue
- Archives of Pediatrics & Adolescent Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2010-04-01
- Volume
- 164
- Issue
- 4
- Pages
- 328
- ISSN
- 1072-4710 (ISSN-L)
- OpenAlex
- W2129022010
- Cited by
- 114
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 9 · 2018: 3 · 2017: 6 · 2016: 11 · 2015: 6 · 2014: 10 · 2013: 8 · 2012: 18
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Archives of Pediatrics and Adolescent Medicine (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- FTO, rs9939609 polymorphism, physical activity, gene-environment interaction, fat mass, adolescents, obesity, body mass index, waist circumference, skinfold thickness, moderate-to-vigorous physical activity, genetic susceptibility
- MeSH terms
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Adipose Tissue, Adolescent, Cross-Sectional Studies, Europe, Female, Humans, Male, Obesity, Polymorphism, Genetic, Proteins, Exercise, Body Mass Index, Body Fat Distribution, Waist Circumference
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