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Provocation of Schizophrenic Symptoms by Intravenous Administration of Methylphenidate
Abstract
Methylphenidate (Ritalin) hydrochloride was administered intravenously to schizophrenic, manic, and depressed patients during the active phase of their illness and upon recovery and to normal. Methylphenidate was found to activate psychotic symptoms in schizophrenics during the active phase of their illness. It failed to produce this effect in the same patients after remission had occurred. It failed to produce a psychotic reaction in most patients with mania and all normal or depressed patients.
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Citations
Cited by
Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression
Grace, A. A. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.57 · Cited by 1,166
The Dopamine Hypothesis of Schizophrenia: A Review*
Meltzer, H. Y., & Stahl, S. M. (1976) · Schizophrenia Bulletin · doi:10.1093/schbul/2.1.19 · Cited by 883
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., & Greenberg, D. (1974) · Science · doi:10.1126/science.184.4143.1243 · Cited by 834
Prevalence of Substance Abuse in Schizophrenia: Demographic and Clinical Correlates
Mueser, K. T., Yarnold, P. R., Levinson, D. F., Singh, H., Bellack, A. S., Kee, K., Morisson, R. L., & Yadalam, K. G. (1990) · Schizophrenia Bulletin · doi:10.1093/schbul/16.1.31 · Cited by 587
Provocative tests with psychostimulant drugs in schizophrenia
Lieberman, J. A., Kane, J. M., & Alvir, J. (1987) · Psychopharmacology · doi:10.1007/bf00216006 · Cited by 532
Metadata
- Authors
- Janowsky, D. S.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1973-02-01
- Volume
- 28
- Issue
- 2
- Pages
- 185
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2033636209
- Cited by
- 310
- References
- 0
- FWCI
- 20.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Janowsky, D. S. (1973). Provocation of Schizophrenic Symptoms by Intravenous Administration of Methylphenidate. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1973.01750320023004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
