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The Experimental Reproduction of Amphetamine Psychosis
Abstract
A large dose of intravenous methamphetamine hydrochloride reproduced the amphetamine psychosis in 12 of 14 patients dependent on amphetamine sulfate and failed to produce a psychosis in two patients who were eventually found to have not used amphetamine regularly above the therapeutic dose range. The psychosis was the facsimile of the disorder observed during drug abuse—a schizophrenic-like state of paranoia in a setting of clear consciousness accompanied by auditory or visual hallucinations, or both, but without thought disorder. Since in some cases the onset of the psychosis was sudden and occurred within one hour of commencing the intravenous injection, hypotheses about depletion of catecholamines and long term metabolites may need to be reconsidered.
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Citations
Cited by
ROBINSON, T., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,106
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Robinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796
Gawin, F. H., & Ellinwood, E. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805053181806 · Cited by 965
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., & Greenberg, D. (1974) · Science · doi:10.1126/science.184.4143.1243 · Cited by 834
Metadata
- Authors
- Bell, D. S.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1973-07-01
- Volume
- 29
- Issue
- 1
- Pages
- 35
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1992372396
- Cited by
- 351
- References
- 0
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bell, D. S. (1973). The Experimental Reproduction of Amphetamine Psychosis. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1973.04200010020003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
