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Cited by 282

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

The Nosological Status of Neurotic Depression: A Prospective Three- to Four-Year Follow-up Examination in Light of the Primary-Secondary and Unipolar-Bipolar Dichotomies

Akiskal, Hagop S.·1978·Archives of General Psychiatry
DOI 10.1001/archpsyc.1978.01770300098011
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Abstract

One hundred patients with "mild" depressive states, variously referred to as "situational," "reactive," or "neurotic," were studied. During a three- to four-year prospective follow-up, 4% had developed bipolar I, 14% bipolar II, and 22% unipolar disorders with predominantly favorable social outcome. Most of the remainder were suffering from nonaffective disorders; in this group, intermittent depressive symptomatology followed a protacted course (paralleling the underlying disorder) with generally unfavorable outcome. Irrespective of diagnostic subtype, a "characterological" component occurring in 24% of the total sample appeared to predict unfavorable prognosis, including three suicides. The diagnostic usage of the concept of neurotic depression may no longer be clinically meaningful, since it lacks sufficient phenomenological characterization and refers to a heterogeneous group of disorders. The data suggest the merits of a biaxial approach to the nosology of depressive disorders whereby phenomenologically based affective diagnoses are qualified as to the presence or absence of character disorder.

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Metadata

Authors
Akiskal, H. S.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1978-06-01
Volume
35
Issue
6
Pages
756
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1978.01770300098011
OpenAlex
W1980851942
Cited by
282
References
51
FWCI
12.66
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Nosological Status of Neurotic Depression: A Prospective Three- to Four-Year Follow-up Examination in Light of the Primary-Secondary and Unipolar-Bipolar Dichotomies. https://app.cochat.ai/papers/10.1001/archpsyc.1978.01770300098011
The paper
Akiskal, H. S. (1978). The Nosological Status of Neurotic Depression: A Prospective Three- to Four-Year Follow-up Examination in Light of the Primary-Secondary and Unipolar-Bipolar Dichotomies. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1978.01770300098011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.