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Fluphenazine vs Placebo in Patients With Remitted, Acute First-Episode Schizophrenia
Abstract
Twenty-eight patients who had recently recovered from an acute-onset, first-episode schizophrenic illness were randomly given fluphenazine hydrochloride or decanoate or placebo for a one-year period in a double-blind study. Seven of 17 patients(14%) receiving placebo experienced a psychotic relapse, whereas none of 11 drug-treated patients experienced a relapse. Eighteen (69%) of the 26 patients available for follow-up (mean interval, 3.5 years) experienced a second psychotic relapse either during the study or afterward, and 50% (14/28) of the original sample experienced a third episode.
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Citations
Cited by
Robinson, D., Woerner, M. G., Alvir, J. M. J., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.3.241 · Cited by 1,327
Barnes, T. R., Drake, R., Paton, C., Cooper, S. J., Deakin, B., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 606
Early intervention in psychosis: concepts, evidence and future directions
MCGORRY, P. D., KILLACKEY, E., & YUNG, A. (2008) · World Psychiatry · doi:10.1002/j.2051-5545.2008.tb00182.x · Cited by 581
The nature of relapse in schizophrenia
Emsley, R., Chiliza, B., Asmal, L., & Harvey, B. H. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-50 · Cited by 478
The Myth of Schizophrenia as a Progressive Brain Disease
Zipursky, R. B., Reilly, T. J., & Murray, R. M. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs135 · Cited by 334
Metadata
- Authors
- Kane, J. M.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1982-01-01
- Volume
- 39
- Issue
- 1
- Pages
- 70
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2061099474
- Cited by
- 222
- References
- 0
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kane, J. M. (1982). Fluphenazine vs Placebo in Patients With Remitted, Acute First-Episode Schizophrenia. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1982.04290010048009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
