The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania: A Controlled, Univariate Analysis
Abstract
Levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in the CSF, and norepinephrine (NE), epinephrine (E), vanillylmandelic acid, normetanephrine, metanephrine, and MHPG in the urine, were measured in 151 hospitalized patients with affective disorders and in 80 healthy controls following a two-week drug-free period. Unipolar and bipolar depressed subjects differed only in NE and E levels. Compared with controls, depressed subjects had higher CSF MHPG levels, women had higher 5-HIAA levels, and men had lower HVA levels. All urinary metabolites were elevated in depression and mania, with the exception of MHPG. The patterns of NE-E differences discriminated among the forms of affective disorders. These data suggest an imbalance of monoamine transmission in depression, characterized by the hyperactive sympathetic nervous system and adrenal medulla. However, MHPG may not be the measure of choice to reflect this imbalance, necessitating measurement of total body monoamine output.
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Cites
An analysis of variance test for normality (complete samples)
SHAPIRO, S. S., & WILK, M. B. (1965) · Biometrika · doi:10.1093/biomet/52.3-4.591 · Cited by 23,480
"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?
Åsberg, M., Thorén, P., Traskman, L., Bertilsson, L., & Ringberger, V. (1976) · Science · doi:10.1126/science.1246632 · Cited by 682
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Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis
Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767
Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.729 · Cited by 613
The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system
Mann, J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00228-1 · Cited by 394
Major Depression in Patients With Agoraphobia and Panic Disorder
Breier, A. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790230015002 · Cited by 317
Metadata
- Authors
- Koslow, S. H.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1983-09-01
- Volume
- 40
- Issue
- 9
- Pages
- 999
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2049019626
- Cited by
- 312
- References
- 2
- FWCI
- 33.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koslow, S. H. (1983). CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania: A Controlled, Univariate Analysis. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1983.01790080081011
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