The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system
Abstract
Numerous abnormalities have been found in the serotonergic system in suicide attempters and completers. There is considerable evidence that the serotonergic system is partly under genetic control and that as yet unknown genetic factors mediate the risk for suicidal behavior independently of the genetic factors responsible for the heritability of major psychiatric conditions associated with suicide. An argument is made that there is a relationship of genetic variants to intermediate phenotypes, such as impulsivity, psychomotor change, pathological aggression and biological abnormalities including specific gene products. A variety of biological indices have been generated by new approaches using postmortem tissue and in vivo imaging that will provide a rich substrate for further genetic studies.
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Specific genes such as 5-HTTLPR that influence neuromaturation have known associations with self-injurious behaviors.
“Specific genes (e.g., 5-HTTLPR; (112, 113)) influencing neuromaturation have known associations with self-injurious behaviors (114, 115).”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [114]
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Cerebrospinal Fluid Amine Metabolites
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Self-citationSerotonergic split brain and suicide
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LUMBAR CSF 5- HYDROXYINDOLEACETIC ACID AND HOMOVANILLIC ACID IN AFFECTIVE SYNDROMES
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Relevance of serotonergic postmortem studies to suicidal behavior
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Serotonin and Major Depression
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Flagged first, then by citations
Cited by
Sorted by citations
Neurobiology of suicidal behaviour
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- Authors
- Mann, J.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Mann, J
- Venue
- Neuropsychopharmacology
- Published
- 2001-05
- Volume
- 24
- Issue
- 5
- Pages
- 467-477
- ISSN
- 0893-133X (ISSN-L)
- OpenAlex
- W2078018408
- Cited by
- 394
- References
- 143
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 12 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 29 · 2012: 16
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA09004, R01AA009004)
- National Institute of Mental Health (-MH56612, R01MH040695, MH46745, MH56390, MH-40210, P30MH055123, R01MH040210, MH 40695, MH 55123)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- suicide, suicide attempts, serotonergic system, serotonin, genetic risk factors, heritability, impulsivity, psychomotor changes, pathological aggression, endophenotypes, postmortem tissue, in vivo brain imaging, gene products
- MeSH terms
- Animals, Brain, Brain Chemistry, Carrier Proteins, Depression, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Receptors, Serotonin, Serotonin, Suicide, Tryptophan Hydroxylase, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins
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