Cited by 394Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on BehaviorGenetic Associations and Epidemiology

The neurobiology and genetics of suicide and attempted suicide: A focus on the serotonergic system

Mann, J·2001·Neuropsychopharmacology

Abstract

Numerous abnormalities have been found in the serotonergic system in suicide attempters and completers. There is considerable evidence that the serotonergic system is partly under genetic control and that as yet unknown genetic factors mediate the risk for suicidal behavior independently of the genetic factors responsible for the heritability of major psychiatric conditions associated with suicide. An argument is made that there is a relationship of genetic variants to intermediate phenotypes, such as impulsivity, psychomotor change, pathological aggression and biological abnormalities including specific gene products. A variety of biological indices have been generated by new approaches using postmortem tissue and in vivo imaging that will provide a rich substrate for further genetic studies.

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Crossref · 10.1016/s0893-133x(00)00228-1

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Authors
Mann, J.
Affiliations
New York State Psychiatric Institute (US)
Corresponding author
Mann, J
Venue
Neuropsychopharmacology
Published
2001-05
Volume
24
Issue
5
Pages
467-477
ISSN
0893-133X (ISSN-L)
OpenAlex
W2078018408
Cited by
394
References
143
Citations by year
2026: 4 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 15 · 2017: 12 · 2016: 18 · 2015: 18 · 2014: 19 · 2013: 29 · 2012: 16
FWCI
4.32
Type
journal article
Language
en
Open access
closed
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA09004, R01AA009004)
  • National Institute of Mental Health (-MH56612, R01MH040695, MH46745, MH56390, MH-40210, P30MH055123, R01MH040210, MH 40695, MH 55123)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
suicide, suicide attempts, serotonergic system, serotonin, genetic risk factors, heritability, impulsivity, psychomotor changes, pathological aggression, endophenotypes, postmortem tissue, in vivo brain imaging, gene products
MeSH terms
Animals, Brain, Brain Chemistry, Carrier Proteins, Depression, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Receptors, Serotonin, Serotonin, Suicide, Tryptophan Hydroxylase, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins

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