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Serotonergic Function in Depression: Prolactin Response to Intravenous Tryptophan in Depressed Patients and Healthy Subjects
Abstract
There is considerable evidence that serotonergic function may be reduced in the brains of depressed patients. Serotonin is an effective stimulant of prolactin release, and intravenous (IV) tryptophan (the amino acid precursor of serotonin), when administered to healthy subjects, produces a reliable and robust increase in serum prolactin level. To evaluate serotonergic function in depressed patients, we gave 25 patients and 19 age- and sex-matched controls tryptophan, 7 g IV. There was a marked blunting of the maximal prolactin response to the tryptophan in both the male and female patients. The patient control differences could not be accounted for on the basis of age, sex, or time without medications. The data provide strong support for a possible serotonergic abnormality in depression.
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Cites
Phase Advance of the Circadian Sleep-Wake Cycle as an Antidepressant
Wehr, T. A., Wirz-Justice, A., Goodwin, F. K., Duncan, W., & Gillin, J. C. (1979) · Science · doi:10.1126/science.227056 · Cited by 528
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Ehlers, C. L. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800340076012 · Cited by 707
Mann, J. J., Huang, Y.-Y., Underwood, M. D., Kassir, S. A., Oppenheim, S., Kelly, T. M., Dwork, A. J., & Arango, V. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.729 · Cited by 613
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The recent progress in animal models of depression
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Metadata
- Authors
- Heninger, G. R.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1984-04-01
- Volume
- 41
- Issue
- 4
- Pages
- 398
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2117122674
- Cited by
- 279
- References
- 1
- FWCI
- 14.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heninger, G. R. (1984). Serotonergic Function in Depression: Prolactin Response to Intravenous Tryptophan in Depressed Patients and Healthy Subjects. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1984.01790150088012
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
