The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Structural Abnormalities in the Frontal System in Schizophrenia: A Magnetic Resonance Imaging Study
Abstract
Thirty-eight schizophrenics and 49 normal controls underwent magnetic resonance imaging. Midline sagittal cuts indicated that the schizophrenics had significantly smaller frontal lobes, as well as smaller cerebrums and craniums. The findings are consistent with some type of early developmental abnormality that might retard brain growth and therefore skull growth. These findings are confirmed on a smaller sample of patients on whom we have coronal cuts. Decreased cerebral and cranial size are associated with prominent negative symptoms, although decreased frontal size is not. Decreased cranial and cerebral size was also associated with impairment on some cognitive tests. These findings are consistent with the hypothesis that some schizophrenics may have a type of early developmental abnormality associated with prominent negative symptoms and cognitive impairment. Further, the results suggest that schizophrenics may have a type of structural frontal system impairment. Thus, they provide anatomic evidence for the "hypofrontality hypothesis."
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Citations
Cites
Studies of interference in serial verbal reactions
Stroop, J. R. (1935) · Journal of Experimental Psychology · doi:10.1037/h0054651 · Cited by 18,622
Go–no go learning after frontal lobe lesions in humans
Drewe, E. A. (1975) · Cortex · doi:10.1016/s0010-9452(75)80015-3 · Cited by 369
Cited by
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674
Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms
Andreasen, N. C., Nopoulos, P., O’Leary, D. S., Miller, D. D., Wassink, T., & Flaum, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00152-3 · Cited by 560
Self-citationKeshavan, M. S., Anderson, S., & Pettergrew, J. W. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90009-4 · Cited by 525
Breier, A. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120009003 · Cited by 513
Metadata
- Authors
- Andreasen, N.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1986-02-01
- Volume
- 43
- Issue
- 2
- Pages
- 136
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2124991752
- Cited by
- 487
- References
- 2
- FWCI
- 33.12
- Type
- journal article
- Language
- en
- Open access
- closed
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