Go–no go learning after frontal lobe lesions in humans
Open accessAbstract
48 patients with unilateral frontal or non-frontal cortical lesions were given a go - no go learning task. Patients with frontal lesions in either hemisphere took longer to learn the task and made more false "go" responses than control patients. They also, unlike controls, took longer to make in correct positive responses than correct positive ones. Medial frontal lesions were found to be particularly important in giving rise to poor performance on this task. It is suggested that this task is non-unitary in nature and that the medial area may be important for more than one ability.
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Findings from electrophysiology, human lesion and functional neuroimaging studies support the crucial role of the pre-SMA in response inhibition.
“Findings from electrophysiology, human lesion and functional neuroimaging studies support the crucial role of the pre-SMA in response inhibition.”
From Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent (2008) · cites this paper as Drewe et al, 1975
In the three largest human frontal lesion studies of response inhibition to date, poor inhibitory performance was associated with lesions of the superior medial frontal lobe.
“In the three largest human frontal lesion studies of response inhibition to date, poor inhibitory performance was associated with lesions of the superior medial frontal lobe (Drewe et al, 1975; Floden & Stuss, 2006; Picton et al., 2006).”
From Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent (2008) · cites this paper as Drewe et al, 1975
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- Authors
- Drewe, E. A.
- Corresponding author
- Drewe, E.A.
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 1975-03
- Volume
- 11
- Issue
- 1
- Pages
- 8-16
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W2092018014
- Cited by
- 369
- References
- 14
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 29 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 15 · 2014: 7 · 2013: 12 · 2012: 12
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- frontal lobe lesions, frontal cortex, medial frontal cortex, response inhibition, hemispheric lateralization
- MeSH terms
- Adult, Brain Diseases, Brain Mapping, Chronic Disease, Cues, Discrimination Learning, Frontal Lobe, Humans, Intelligence, Middle Aged, Psychosurgery, Reaction Time, Serial Learning, Time Factors
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