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Cited by 333

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Seizure Threshold in Electroconvulsive Therapy: Effects of Sex, Age, Electrode Placement, and Number of Treatments

Sackeim, Harold·1987·Archives of General Psychiatry

Abstract

In a random-assignment trial to unilateral right and bilateral electrode placements, electroconvulsive therapy (ECT) stimulus intensity was titrated to just above seizure threshold for each of 52 depressed patients. Seizure threshold was quantified in units of charge. There was a 12-fold range in the minimum electrical intensity necessary to produce seizure. Sex, age, electrode placement, and the cumulative number of treatments were each associated with seizure threshold. Bilateral ECT had both a higher initial seizure threshold and a greater cumulative increase in seizure threshold compared with unilateral ECT. Clinical and research implications are discussed with respect to dosing strategies in ECT.

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Crossref · 10.1001/archpsyc.1987.01800160067009

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Metadata

Authors
Sackeim, H.
Venue
Archives of General Psychiatry
Published
1987-04-01
Volume
44
Issue
4
Pages
355
ISSN
0003-990X (ISSN-L)
OpenAlex
W2010423644
Cited by
333
References
1
FWCI
7.80
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Seizure Threshold in Electroconvulsive Therapy: Effects of Sex, Age, Electrode Placement, and Number of Treatments. https://app.cochat.ai/papers/10.1001/archpsyc.1987.01800160067009
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Sackeim, H. (1987). Seizure Threshold in Electroconvulsive Therapy: Effects of Sex, Age, Electrode Placement, and Number of Treatments. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1987.01800160067009

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