The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Age and Regional Cerebral Blood Flow at Rest and During Cognitive Activity
Abstract
The relationship between age and regional cerebral blood flow (rCBF) activation for cognitive tasks was investigated with the xenon Xe 133 inhalation technique. The sample consisted of 55 healthy subjects, ranging in age from 18 to 72 years, who were studied during rest and during the performance of verbal analogy and spatial orientation tasks. The dependent measures were indexes of gray-matter rCBF and average rCBF (gray and white matter) as well as the percentage of gray-matter tissue. Advanced age was associated with reduced flow, particularly pronounced in anterior regions. However, the extent and pattern of rCBF changes during cognition was unaffected by age. For the percentage of gray matter, there was a specific reduction in anterior regions of the left hemisphere. The findings suggest the utility of this research paradigm for investigating neural underpinnings of the effects of dementia on cognitive functioning, relative to the effects of normal aging.
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Cites
Kuhl, D. E., Metter, E. J., Riege, W. H., & Phelps, M. E. (1982) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1982.15 · Cited by 338
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(1998) · PubMed · doi:10.1176/ajp.155.3.344 · Cited by 784
Keshavan, M. S., Anderson, S., & Pettergrew, J. W. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90009-4 · Cited by 525
Gur, R. C., Richard, J., Hughett, P., Calkins, M. E., Macy, L., Bilker, W. B., Brensinger, C., & Gur, R. E. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.11.017 · Cited by 528
Self-citationTraining for attentional control in dual task settings: a comparison of young and old adults.
Kramer, A. F., Larish, J. F., & Strayer, D. L. (1995) · Journal of Experimental Psychology Applied · doi:10.1037/1076-898x.1.1.50 · Cited by 413
An fMRI Study of Sex Differences in Regional Activation to a Verbal and a Spatial Task
Gur, R. C., Alsop, D., Glahn, D., Petty, R., Swanson, C. L., Maldjian, J. A., Turetsky, B. I., Detre, J. A., Gee, J., & Gur, R. E. (2000) · Brain and Language · doi:10.1006/brln.2000.2325 · Cited by 352
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Metadata
- Authors
- Gur, R. C.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1987-07-01
- Volume
- 44
- Issue
- 7
- Pages
- 617
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1991059506
- Cited by
- 196
- References
- 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gur, R. C. (1987). Age and Regional Cerebral Blood Flow at Rest and During Cognitive Activity. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1987.01800190037006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
