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Cited by 265

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Carbon Dioxide—Induced Anxiety: Behavioral, Physiologic, and Biochemical Effects of Carbon Dioxide in Patients With Panic Disorders and Healthy Subjects

Woods, Scott W.·1988·Archives of General Psychiatry
DOI 10.1001/archpsyc.1988.01800250051007
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Abstract

Carbon dioxide was administered for 15 minutes to patients with panic disorders (5% CO2, n = 14) and healthy subjects (5% CO2, n = 11; 7.5% CO2, n = 8). Following administration of CO2 and air placebo, changes in behavioral ratings, vital signs, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol, cortisol, growth hormone, and prolactin were measured over three hours. In the healthy subjects, CO2 produced dose-related increases in anxiety, somatic symptoms, vital signs, and plasma cortisol levels. In the patients, the frequency of panic attacks (in eight of 14 patients) and the increases in anxiety and somatic symptoms induced by 5% CO2 exceeded those in the healthy subjects and were similar to those induced by 7.5% CO2 in the healthy subjects. The physiologic and biochemical measurements obtained did not elucidate the mechanisms underlying CO2-induced anxiety or the greater anxiogenic effects of CO2 seen in patients with panic disorders.

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Metadata

Authors
Woods, S. W.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1988-01-01
Volume
45
Issue
1
Pages
43
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1988.01800250051007
OpenAlex
W2140176228
Cited by
265
References
43
FWCI
21.30
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Carbon Dioxide—Induced Anxiety: Behavioral, Physiologic, and Biochemical Effects of Carbon Dioxide in Patients With Panic Disorders and Healthy Subjects. https://app.cochat.ai/papers/10.1001/archpsyc.1988.01800250051007
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Woods, S. W. (1988). Carbon Dioxide—Induced Anxiety: Behavioral, Physiologic, and Biochemical Effects of Carbon Dioxide in Patients With Panic Disorders and Healthy Subjects. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1988.01800250051007

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