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Pathological Gambling: A Psychobiological Study
Abstract
We investigated psychobiological substrates of pathological gambling by measuring levels of norepinephrine, monoamine metabolites, and peptides in cerebrospinal fluid, plasma, and urine. Pathological gamblers had a significantly higher centrally produced fraction of cerebrospinal fluid levels of 3-methoxy-4-hydroxyphenylglycol as well as significantly greater urinary outputs of norepinephrine than controls. These results suggest that pathological gamblers may have a functional disturbance of the noradrenergic system. This system has been postulated to underlie sensation-seeking behaviors, aspects of which are thought to be abnormal among pathological gamblers.
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Citations
Cited by
Pathological gambling: Etiology, comorbidity, and treatment.
Petry, N. M. (2005) · doi:10.1037/10894-000 · Cited by 659
Raylu, N., & Oei, T. P. S. (2002) · Clinical Psychology Review · doi:10.1016/s0272-7358(02)00101-0 · Cited by 517
The neurobiology of pathological gambling and drug addiction: an overview and new findings
Potenza, M. N. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0100 · Cited by 508
Leeman, R. F., & Potenza, M. N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2550-7 · Cited by 448
Common Genetic Vulnerability for Pathological Gambling and Alcohol Dependence in Men
Slutske, W. S. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.666 · Cited by 441
Metadata
- Authors
- Roy, A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1988-04-01
- Volume
- 45
- Issue
- 4
- Pages
- 369
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1977741407
- Cited by
- 277
- References
- 0
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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