The neurobiology of pathological gambling and drug addiction: an overview and new findings
Open accessAbstract
Gambling is a prevalent recreational behaviour. Approximately 5% of adults have been estimated to experience problems with gambling. The most severe form of gambling, pathological gambling (PG), is recognized as a mental health condition. Two alternate non-mutually exclusive conceptualizations of PG have considered it as an obsessive-compulsive spectrum disorder and a ‘behavioural’ addiction. The most appropriate conceptualization of PG has important theoretical and practical implications. Data suggest a closer relationship between PG and substance use disorders than exists between PG and obsessive-compulsive disorder. This paper will review data on the neurobiology of PG, consider its conceptualization as a behavioural addiction, discuss impulsivity as an underlying construct, and present new brain imaging findings investigating the neural correlates of craving states in PG as compared to those in cocaine dependence. Implications for prevention and treatment strategies will be discussed.
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Studies in support of the classification of gambling disorder as a "behavioral addiction" have produced robust evidence for behavioral, cognitive, and biological similarities between gambling disorder and substance use disorders.
“Moreover, studies in support of the classification of gambling disorder as a “behavioral addiction” have produced robust evidence for behavioral, cognitive, and biological similarities between gambling disorder and substance use disorders (Di Nicola et al., 2015; Leeman & Potenza, 2012; 2013; Potenza, 2008; Slutske, Ellingson, Richmond-Rakerd, Zhu, & Martin, 2013).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Potenza, 2008
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Mesolimbic dopamine release is linked to symptom severity in pathological gambling
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Boileau, I., Payer, D., Chugani, B., Lobo, D., Behzadi, A., Rusjan, P. M., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., et al. (2013) · Addiction · doi:10.1111/add.12066 · Cited by 190 · see citing works
Brain activity during cocaine craving and gambling urges: an fMRI study
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Di Nicola, M., Tedeschi, D., De Risio, L., Pettorruso, M., Martinotti, G., Ruggeri, F., Swierkosz-Lenart, K., Guglielmo, R., Callea, A., Ruggeri, G., et al. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.12.028 · Cited by 143 · see citing works
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Compulsivity, impulsivity, and the DSM-5 process
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Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers
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Neurocognitive mechanisms in compulsive sexual behavior disorder
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Cue-Induced Craving Increases Impulsivity via Changes in Striatal Value Signals in Problem Gamblers
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“(Desai & Potenza, 2008; Kessler et al., 1994).”
InfluentialIs excessive use of social media an addiction?
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- Authors
- Potenza, M. N.
- Affiliations
- Yale University (US)
- Corresponding author
- Potenza, Marc N
- ORCID
- Potenza, Marc N
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2008-07-18
- Volume
- 363
- Issue
- 1507
- Pages
- 3181-3189
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC2607329
- OpenAlex
- W2069156693
- Cited by
- 508
- References
- 91
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 18 · 2023: 9 · 2022: 13 · 2021: 18 · 2020: 61 · 2019: 25 · 2018: 27 · 2017: 28 · 2016: 31 · 2015: 32 · 2014: 46 · 2013: 39 · 2012: 44
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1ul1rr024925-01)
- National Institute on Alcohol Abuse and Alcoholism (P50 AA12870, P50AA015632, RL1AA017539, P50AA012870)
- National Institute on Drug Abuse (P50DA016556, P50DA009241, R01DA019039, R01DA020908, P50-DA-0-9241, P50-DA16556)
- National Center for Research Resources (UL1-RR024925)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- gambling addiction, drug addiction, neurobiology, behavioral addiction, obsessive-compulsive spectrum disorders, impulsivity, craving, cocaine dependence, neural correlates, substance use disorders, prevention and treatment
- MeSH terms
- Gambling, Humans, Models, Biological, Neurobiology, Neurotransmitter Agents, Substance-Related Disorders
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