The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Controlled Study of Haloperidol, Pimozide, and Placebo for the Treatment of Gilles de la Tourette's Syndrome
Abstract
The results of this controlled study of the treatment of 57 patients with Gilles de la Tourette's syndrome suggested that both haloperidol and pimozide were more effective than placebo, but that haloperidol was slightly more effective than pimozide. Adverse effects occurred more frequently with haloperidol vs placebo than with pimozide vs placebo, but the frequency was not significantly different for haloperidol compared with pimozide. Clinically significant cardiac effects did not occur at a maximum dosage of 0.3 mg/kg or 20 mg/d for pimozide and 10 mg/d for haloperidol. However, the QTc interval was prolonged during pimozide treatment compared with that during haloperidol treatment, although the values for both medications were not in an abnormal range.
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Citations
Cites
Receptor activity and turnover of dopamine and noradrenaline after neuroleptics
Andén, N.-E., Butcher, S. G., Corrodi, H., Fuxe, K., & Ungerstedt, U. (1970) · European Journal of Pharmacology · doi:10.1016/0014-2999(70)90006-3 · Cited by 1,026
Seeman, P., & Lee, T. (1975) · Science · doi:10.1126/science.1145194 · Cited by 869
The Two-Period Change-Over Design and Its Use in Clinical Trials
Grizzle, J. E. (1965) · Biometrics · doi:10.2307/2528104 · Cited by 784
Gilles de la Tourette Syndrome
(2021) · Encyclopedia of Autism Spectrum Disorders · doi:10.1007/978-3-319-91280-6_300752 · Cited by 535
Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?
Matthysse, S. (1973) · PubMed · Cited by 341
Clonidine Ameliorates Gilles de la Tourette Syndrome
Cohen, D. J. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780250036004 · Cited by 263
Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists.
Gould, R. J., Murphy, K. M., Reynolds, I. J., & Snyder, S. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.16.5122 · Cited by 218
Controlled Study of Pimozide vs. Placebo in Tourette's Syndrome
SHAPIRO, A. K., & SHAPIRO, E. (1984) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198403000-00007 · Cited by 194
Self-citationAn exact test for comparing matched proportions in crossover designs
GART, J. J. (1969) · Biometrika · doi:10.1093/biomet/56.1.75 · Cited by 178
A comparison of pimozide and haloperidol in the treatment of Gilles de la Tourette's syndrome
Ross, M. S., & Moldofsky, H. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.5.585 · Cited by 152
Cited by
Tourette syndrome, associated conditions and the complexities of treatment
Robertson, M. M. (2000) · Brain · doi:10.1093/brain/123.3.425 · Cited by 704
Leckman, J. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11526-1 · Cited by 685
Bloch, M. H., Landeros-Weisenberger, A., Kelmendi, B., Coric, V, Bracken, M. B., & Leckman, J. F. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001823 · Cited by 635
Scahill, L., Chappell, P. B., Kim, Y. S., Schultz, R. T., Katsovich, L., Shepherd, E., Arnsten, A. F. T., Cohen, D. J., & Leckman, J. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1067 · Cited by 588
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson, B. S., Thomas, P., Kane, M. J., Scahill, L., Zhang, H., Bronen, R., King, R. A., Leckman, J. F., & Staib, L. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.4.415 · Cited by 527
Metadata
- Authors
- Shapiro, E.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1989-08-01
- Volume
- 46
- Issue
- 8
- Pages
- 722
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2119615820
- Cited by
- 355
- References
- 23
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shapiro, E. (1989). Controlled Study of Haloperidol, Pimozide, and Placebo for the Treatment of Gilles de la Tourette's Syndrome. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1989.01810080052006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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