The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain: A Study Using Positron Emission Tomography and [Fluorine 18]-Fluorodeoxyglucose
Abstract
We examined the effects of cocaine hydrochloride (40 mg intravenously) on regional cerebral metabolic rates for glucose and on subjective self-reports of eight polydrug abusers in a double-blind, placebo-controlled, crossover study. The regional cerebral metabolic rate for glucose was measured by the [fluorine 18]-fluorodeoxyglucose method, using positron emission tomography. With eyes covered, subjects listened to a tape that presented white noise, "beep" prompts, and questions about subjective effects of cocaine or saline. Cocaine produced euphoria and reduced glucose utilization globally (mean reduction, 14%). Twenty-six of 29 brain regions (all neocortical areas, basal ganglia, portions of the hippocampal formation, thalamus, and midbrain) showed significant decrements (5% to 26%) in the regional cerebral metabolic rate for glucose. No significant effects of cocaine were observed in the pons, the cerebellar cortex, or the vermis. Right-greater-than-left hemispheric asymmetry of regional cerebral metabolic rates for glucose occurred in the lateral thalamus. The findings demonstrate that reduced cerebral metabolism is associated with cocaine-induced euphoria.
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Metadata
- Authors
- London, E. D.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1990-06-01
- Volume
- 47
- Issue
- 6
- Pages
- 567
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2126884841
- Cited by
- 305
- References
- 43
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain: A Study Using Positron Emission Tomography and [Fluorine 18]-Fluorodeoxyglucose. https://app.cochat.ai/papers/10.1001/archpsyc.1990.01810180067010
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- London, E. D. (1990). Cocaine-Induced Redoppuction of Glucose Utilization in Human Brain: A Study Using Positron Emission Tomography and [Fluorine 18]-Fluorodeoxyglucose. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1990.01810180067010
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.