Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

Ritz, Mary C.; Lamb, R. J..; Goldberg, Steven R.; Kuhar, Michael J.

doi:10.1126/science.2820058

Cited by 2,180Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

Ritz, Mary C., Lamb, R. J.., Goldberg, Steven R., Kuhar, Michael J.·1987·Science

DOI 10.1126/science.2820058

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Abstract

Although cocaine binds to several sites in the brain, the biochemical receptor mechanism or mechanisms associated with its dependence producing properties are unknown. It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [ 3 H]mazindol binding to the dopamine transporters in the rat striatum, but not with their potencies in binding to a large number of other presynaptic and postsynaptic binding sites. Thus, the cocaine receptor related to substance abuse is proposed to be the one associated with dopamine uptake inhibition.

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DA is essential for the self-administration of drugs of abuse in rodents, for which the mesolimbic pathway is a crucial substrate.
“Behavioral studies in rodents also indicate that DA is essential for the self-administration of drugs of abuse for which the mesolimbic pathway has been identified as a crucial substrate [114,128].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [128]

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Authors: Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J.
Affiliations: National Institute on Drug Abuse (US)
ORCID: Lamb, R. J..
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1987-09-04
Volume: 237
Issue: 4819
Pages: 1219-1223
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2820058
OpenAlex: W2095217951
Cited by: 2,180
References: 72
Citations by year: 2026: 8 · 2025: 14 · 2024: 22 · 2023: 26 · 2022: 22 · 2021: 34 · 2020: 26 · 2019: 24 · 2018: 44 · 2017: 35 · 2016: 36 · 2015: 53 · 2014: 50 · 2013: 54 · 2012: 57
FWCI: 14.56
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: dopamine transporter, cocaine self-administration, cocaine dependence, dopamine uptake inhibition, striatum, drug potency
MeSH terms: Animals, Haplorhini, Brain, Cattle, Cocaine, Corpus Striatum, Dopamine, Male, Mazindol, Norepinephrine, Rats, Inbred Strains, Receptors, Adrenergic, Receptors, Dopamine, Receptors, Serotonin, Self Administration, Serotonin, Rats

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Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

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