The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims
Abstract
Suicidal behavior has been linked to a deficiency in serotonin neurotransmission, but it is not known which brain regions are involved. We determined the pattern of alteration in serotonin 5-HT2 (5-HT2) receptor binding sites in suicide victims in prefrontal cortex compared with temporal cortex using a matched-pairs design to study 11 suicide victims and 11 matched controls, by both membrane binding and quantitative receptor autoradiography. Since a relationship between the serotonergic and noradrenergic systems has been proposed, we also examined beta-adrenergic receptor binding sites. Binding to 5-HT2 and beta-adrenergic sites in slide-mounted sections correlated strongly with binding site number in membrane preparations. A specific laminar distribution of 5-HT2 binding sites was found in both the control and suicide groups, whereas beta-adrenergic binding sites did not differ across cortical layers. A significant increase was found in suicide victims across all cortical layers in both receptor subpopulations in the prefrontal cortex, but only beta-adrenergic sites were increased in the temporal cortex. We conclude that suicide is associated with a localized increase in 5-HT2 binding sites.
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Siever, L. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111774 · Cited by 984
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Metadata
- Authors
- Arango, V.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1990-11-01
- Volume
- 47
- Issue
- 11
- Pages
- 1038
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2144665117
- Cited by
- 420
- References
- 86
- FWCI
- 20.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Arango, V. (1990). Autoradiographic Demonstration of Increased Serotonin 5-HT2 and β-Adrenergic Receptor Binding Sites in the Brain of Suicide Victims. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1990.01810230054009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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