Cited by 1,828Substance Abuse Treatment and OutcomesAlcohol Consumption and Health EffectsAlcoholism and Thiamine Deficiency

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Naltrexone in the Treatment of Alcohol Dependence

Volpicelli, Joseph R.·1992·Archives of General Psychiatry

DOI 10.1001/archpsyc.1992.01820110040006

Open this paper in CoChat — free account

Abstract

Seventy male alcohol-dependent patients participated in a 12-week, double-blind, placebo-controlled trial of naltrexone hydrochloride (50 mg/d) as an adjunct to treatment following alcohol detoxification. Subjects taking naltrexone reported significantly less alcohol craving and days in which any alcohol was consumed. During the 12-week study, only 23% of the naltrexone-treated subjects met the criteria for a relapse, whereas 54.3% of the placebo-treated subjects relapsed. The primary effect of naltrexone was seen in patients who drank any alcohol while attending outpatient treatment. Nineteen (95%) of the 20 placebo-treated patients relapsed after they sampled alcohol, while only eight (50%) of 16 naltrexone-treated patients exposed to alcohol met relapse criteria. Naltrexone was not associated with mood changes or other psychiatric symptoms. Significant side effects (nausea) occurred in two naltrexone-treated subjects, and one naltrexone-treated subject complained of increased pain from arthritis. These results suggest that naltrexone may be a safe and effective adjunct to treatment in alcohol-dependent subjects, particularly in preventing alcohol relapse.

Integrity signals

Registry

Crossref · 10.1001/archpsyc.1992.01820110040006

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Hopkins Symptom Checklist (HSCL): A self-report symptom inventory
Derogatis, L. R., Lipman, R. S., Rickels, K., Uhlenhuth, E. H., & Covi, L. (1974) · Behavioral Science · doi:10.1002/bs.3830190102 · Cited by 4,604
Survival Analysis
Miller, R. G. (1981) · Cited by 3,336
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.256.11.1449 · Cited by 541
Alteration of ethanol self-administration by naltrexone
Altshuler, H. L., Phillips, P. E., & Feinhandler, D. A. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90257-x · Cited by 397
The Effectiveness of Alcoholism Treatment
Miller, W. R., & Hester, R. K. (1986) · Springer eBooks · doi:10.1007/978-1-4613-2191-0_7 · Cited by 276
The serotonin uptake inhibitor citalopram attenuates ethanol intake
Naranjo, C. A., Sellers, E. M., Sullivan, J. T., Woodley-Remus, D., Kadlec, K. E., & Sykora, K. (1987) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1987.27 · Cited by 236
Naltrexone blocks the post-shock increase of ethanol consumption
Volpicelli, J. R., Davis, M. A., & Olgin, J. E. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90601-6 · Cited by 187
Self-citation
Antagonism by naltrexone of voluntary alcohol selection in the chronically drinking macaque monkey
Myers, R. D., Borg, S., & Mossberg, R. (1986) · Alcohol · doi:10.1016/0741-8329(86)90058-3 · Cited by 167
Lithium Treatment of Depressed and Nondepressed Alcoholics
Dorus, W. (1989) · JAMA · doi:10.1001/jama.1989.03430120100029 · Cited by 164
Oral ethanol self-administration in the rat: Effect of naloxone
Samson, H. H., & Doyle, T. F. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90491-5 · Cited by 162

Show all 23 references

Sorted by citations

Items 801–900 of 1,004

Metabolic determinants of binge eating
Drewnowski, A. (1995) · Addictive Behaviors · doi:10.1016/0306-4603(95)00105-0 · Cited by 32
The Pharmacotherapy of Alcohol Dependence: A State of the Art Review
Sousa, A. D. (2010) · Mens Sana monographs · doi:10.4103/0973-1229.58820 · Cited by 31
Pharmacotherapy for Tobacco Dependence
Fant, R. V., Buchhalter, A. R., Buchman, A. C., & Henningfield, J. E. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-69248-5_17 · Cited by 34
Pharmacologic management of relapse prevention in addictive disorders
Sofuoglu, M., & Kosten, T. R. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.06.002 · Cited by 32
Patterns of Urges During Early Abstinence in Alcohol‐dependent Subjects
Krahn, D. D., Bohn, M. J., Henk, H. J., Grossman, J. L., & Gosnell, B. A. (2005) · American Journal on Addictions · doi:10.1080/10550490590949424 · Cited by 32
Fluvoxamine treatment of alcoholic amnestic disorder
Martin, P. (1995) · European Neuropsychopharmacology · doi:10.1016/0924-977x(94)00129-y · Cited by 32
Effects of Chronic Alcohol on Immunoreactive β‐Endorphin Secretion from Hypothalamic Neurons in Primary Cultures: Evidence for Alcohol Tolerance, Withdrawal, and Sensitization Responses
Boyadjieva, N. I., & Sarkar, D. K. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb01456.x · Cited by 32
Pimecrolimus cream 1% can be an effective treatment for seborrheic dermatitis of the face and trunk.
Rallis, E. A., Nasiopoulou, A., KOUSKOUKIS, C. E., & Koumantaki, E. (2004) · PubMed · Cited by 32
Relapse Prevention in Alcoholism
Soyka, M. (1997) · CNS Drugs · doi:10.2165/00023210-199707040-00004 · Cited by 32
Pharmacogenetics of Addiction Therapy
Nielsen, D. A., Nielsen, E. M., Dasari, T., & Spellicy, C. J. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0956-8_15 · Cited by 32
Interaction Between Family History of Alcoholism and Locus of Control in the Opioid Regulation of Impulsive Responding Under the Influence of Alcohol
Altamirano, L. J., Fields, H. L., D’Esposito, M., & Boettiger, C. A. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01535.x · Cited by 33
A double-blind, placebo-controlled study of sertraline with naltrexone for alcohol dependence
Farren, C. K., Scimeca, M. M., Wu, R., & Malley, S. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.06.006 · Cited by 31
Extended-Release Naltrexone and Harm Reduction Counseling for Chronically Homeless People with Alcohol Dependence
Collins, S. E., Duncan, M. H., Smart, B. F., Saxon, A. J., Malone, D. K., Jackson, T. R., & Ries, R. K. (2014) · Substance Abuse · doi:10.1080/08897077.2014.904838 · Cited by 33
Use of Naltrexone in the Treatment of Alcoholism Nationally in the Department of Veterans Affairs
Petrakis, I. L., LESLIE, D. L., & Rosenheck, R. A. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000095861.43232.19 · Cited by 31
Naltrexone and alcohol drinking in mice lacking β-endorphin by site-directed mutagenesis
Grahame, N. J., Mosemiller, A. K., Low, M. J., & Froehlich, J. C. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00411-1 · Cited by 31
Gender Differences in Predictors of Treatment Attrition with High Dose Naltrexone in Cocaine and Alcohol Dependence
Suh, J. J., Pettinati, H. M., Kampman, K. M., & O’Brien, C. P. (2008) · American Journal on Addictions · doi:10.1080/10550490802409074 · Cited by 30
Nicotine dependence is associated with compulsive alcohol craving
Hillemacher, T., Bayerlein, K., Wilhelm, J., Frieling, H., Thürauf, N., Ziegenbein, M., Kornhuber, J., & Bleich, S. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01442.x · Cited by 31
Amisulpride Does Not Prevent Relapse in Primary Alcohol Dependence: Results of a Pilot Randomized, Placebo-Controlled Trial
Marra, D., Warot, D., Berlin, I., Hispard, É., Notides, C., Tilikete, S., Payan, C., Lépine, J., Dally, S., & Aubin, H. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200210000-00012 · Cited by 31
Naltrexone potentiates anti-HIV-1 activity of antiretroviral drugs in CD4+ lymphocyte cultures
Gekker, G., Lokensgard, J. R., & Peterson, P. K. (2001) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(01)00140-5 · Cited by 31
Atypical Antipsychotic Medication and Substance Use‐Related Outcomes in the Treatment of Schizophrenia
Petrakis, I. L., LESLIE, D. L., Finney, J. W., & Rosenheck, R. A. (2006) · American Journal on Addictions · doi:10.1080/10550490500419052 · Cited by 31
Differences in the Responses of the Pituitary β‐Endorphin and Cardiovascular System to Ethanol and Stress as a Function of Family History
Dai, X., Thavundayil, J., & Gianoulakis, C. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02653.x · Cited by 31
Opioid antagonists for smoking cessation
David, S. P., Lancaster, T., & Stead, L. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003086 · Cited by 31
Effect of opioid receptor blockade on acetaldehyde self-administration and ERK phosphorylation in the rat nucleus accumbens
Peana, A. T., Muggironi, G., Fois, G. R., Zinellu, M., Vinci, S., & Acquas, E. (2011) · Alcohol · doi:10.1016/j.alcohol.2011.06.003 · Cited by 30
A Model of Alcohol Drinking under an Intermittent Access Schedule Using Group-Housed Mice
Smutek, M., Turbasa, M., Sikora, M., Piechota, M., Zajdel, J., Przewłocki, R., & Parkitna, J. M. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096787 · Cited by 30
Naltrexone (50 mg) Plus Psychotherapy in Alcohol-Dependent Patients: A Meta-Analysis of Randomized Controlled Trials
Jarosz, J., Miernik, K., Wąchal, M., Walczak, J., & Krumpl, G. (2013) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2013.796961 · Cited by 30
Methodology of a randomized double-blind clinical trial for comorbid posttraumatic stress disorder and alcohol dependence
Foa, E., & Williams, M. T. (2010) · Mental Health and Substance Use · doi:10.1080/17523281003738661 · Cited by 34
Building Bridges: The Transdisciplinary Study of Craving From the Animal Laboratory to the Lamppost
Monti, P. M., Tidey, J. W., Czachowski, C. L., Grant, K. A., Rohsenow, D. J., Sayette, M. A., Maners, N., & Pierre, P. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000113422.04849.fa · Cited by 30
Chronic Ethanol Consumption in Rats Produces Opioid Antinociceptive Tolerance through Inhibition of Mu Opioid Receptor Endocytosis
Li, H., & Whistler, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019372 · Cited by 30
Effects of acute ethanol on corticotropin-releasing hormone and β-endorphin systems at the level of the rat central amygdala
Lam, M. P., & Gianoulakis, C. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2337-x · Cited by 32
The Declining Efficacy of Naltrexone Pharmacotherapy for Alcohol Use Disorders Over Time: A Multivariate Meta‐Analysis
Re, A. C. D., Maisel, N. C., Blodgett, J. C., & Finney, J. W. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12067 · Cited by 30
Influence of cue exposure on inhibitory control and brain activation in patients with alcohol dependence
Mainz, V. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00092 · Cited by 30
Continuum of Care
Johnson, S. (2003) · Elsevier eBooks · doi:10.1016/b978-012387581-5/50007-0 · Cited by 30
Reliability of Multidimensional Substance Abuse Treatment Matching
Baker, S. L., & Gastfriend, D. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v22s01_04 · Cited by 30
Naltrexone in the Treatment of Alcohol Dependence
Unterwald, E. M. (2008) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318182b20f · Cited by 30
Hypericum perforatum CO2 Extract and Opioid Receptor Antagonists Act Synergistically to Reduce Ethanol Intake in Alcohol‐Preferring Rats
Perfumi, M. C., Santoni, M., Cippitelli, A., Ciccocioppo, R., Froldi, R., & Massi, M. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000092062.60924.56 · Cited by 30
Effect of naltrexone on oral consumption of concurrently available ethanol and cocaine in the rat
Stromberg, M. F., Sengpiel, T., Mackler, S. A., Volpicelli, J. R., O’Brien, C. P., & Vogel, W. H. (2002) · Alcohol · doi:10.1016/s0741-8329(02)00280-x · Cited by 30
Self-citation
PERSONALITY AND ALCOHOL/SUBSTANCE-USE DISORDER PATIENT RELAPSE AND ATTENDANCE AT SELF-HELP GROUP MEETINGS
Janowsky, D. S. (1999) · Alcohol and Alcoholism · doi:10.1093/alcalc/34.3.359 · Cited by 30
Pharmacological Relapse Prevention in Alcohol Dependence: From Animal Models to Clinical Trials
Boening, J., Lesch, O. M., Spanagel, R., Wolffgramm, J., Narita, M., Sinclair, D., Mason, B. J., & Wiesbeck, G. A. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02386.x · Cited by 30
Pharmacological treatment of alcoholism
Gatch, M. B., & Lal, H. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00060-8 · Cited by 30
Clinical Medications Development for Opiate Addiction: Focus on Nonopioids and Opioid Antagonists for the Amelioration of Opiate Withdrawal Symptoms and Relapse Prevention
Herman, B. H., & O’Brien, C. P. (1997) · Seminars in Neuroscience · doi:10.1006/smns.1997.0115 · Cited by 30
International Update: New Findings on Promising Medications
Litten, R. Z., & Fertig, J. B. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01779.x · Cited by 30
Integrated Management of Physician‐delivered Alcohol Care for Tuberculosis Patients: Design and Implementation
Greenfield, S. F., Shields, A. L., Connery, H. S., Livchits, V., Yanov, S. A., Lastimoso, C. S., Strelis, A. K., Mishustin, S. P., Fitzmaurice, G. M., Mathew, T. A., et al. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01094.x · Cited by 29
A Rational Approach to the Pharmacotherapy of Alcohol Dependence
Petrakis, I. L. (2006) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000248602.68607.81 · Cited by 29
An open randomized trial comparing disulfiram and naltrexone in adolescents with alcohol dependence
Sousa, A. D., & Sousa, A. D. (2008) · Journal of Substance Use · doi:10.1080/14659890802305861 · Cited by 29
The role of endogenous beta-endorphin and enkephalins in ethanol reward
Tseng, A., Nguyen, K. N. T., Hamid, A., Garg, M., Marquez, P. V., & Lutfy, K. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.001 · Cited by 29
A Longitudinal Examination of Alcohol Pharmacotherapy Adoption in Substance Use Disorder Treatment Programs: Patterns of Sustainability and Discontinuation
Abraham, A. J., Knudsen, H. K., & Roman, P. M. (2011) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2011.72.669 · Cited by 29
Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity
Cservenka, A., Yardley, M. M., & Ray, L. A. (2016) · American Journal on Addictions · doi:10.1111/ajad.12463 · Cited by 30
Pharmacokinetics of Long‐Acting Naltrexone in Subjects With Mild to Moderate Hepatic Impairment
Turncliff, R. Z., Dunbar, J., Dong, Q., Silverman, B. L., Ehrich, E. W., Dilzer, S. C., & Lasseter, K. C. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005280199 · Cited by 29
Liver transplantation for alcoholic liver disease
Burra, P., & Lucey, M. R. (2013) · Clinical Liver Disease · doi:10.1002/cld.204 · Cited by 29
Does electroacupuncture reduce craving for alcohol? A randomized controlled study
Rampes, H., Pereira, S., Mortimer, A. M., Manoharan, S. A., & Knowles, M. (1997) · Complementary Therapies in Medicine · doi:10.1016/s0965-2299(97)80085-4 · Cited by 29
Naloxone reverses disinhibitory/aggressive behavior in 5,7-DHT-lesioned rats; involvement of GABAA receptor blockade?
Söderpalm, B., & Svensson, A. I. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00076-3 · Cited by 29
Medications for Alcohol, Illicit Drug, and Tobacco Dependence
Litten, R. Z., & Allen, J. P. (1999) · Journal of Substance Abuse Treatment · doi:10.1016/s0740-5472(98)00028-2 · Cited by 29
Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment
Doty, P., Kirk, J. M., Cramblett, M., & de Wit, H. (1997) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(97)00094-x · Cited by 29
Behavioral and Neurochemical Studies in Distinct Animal Models of Ethanols Motivational Effects
Camarini, R., Pautassi, R. M., Méndez, M., Quadros, I. M., Formigoni, M. L. O. D. S., & Boerngen-Lacerda, R. (2010) · Current Drug Abuse Reviews · doi:10.2174/1874473711003040205 · Cited by 30
Attenuation of the Stimulant Response to Ethanol is Associated with Enhanced Ataxia for a GABAA, but not a GABAB, Receptor Agonist
Holstein, S. E., Dobbs, L. K., & Phillips, T. J. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00817.x · Cited by 29
Effects of Naltrexone During the Descending Limb of the Blood Alcohol Curve
Ray, L. A., Hutchison, K. E., MacKillop, J. M., Miranda, R., Audette, A., Swift, R. M., & Monti, P. M. (2008) · American Journal on Addictions · doi:10.1080/10550490802138400 · Cited by 28
μ1-opioid antagonist naloxonazine alters ethanol discrimination and consumption
Mhatre, M., & Holloway, F. A. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00021-1 · Cited by 28
Effect of the combination of naltrexone and acamprosate on alcohol intake in mice
Kim, S.-G., HAN, B., PARK, J., KIM, M., & Stromberg, M. F. (2003) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2004.01189.x · Cited by 28
ADJUVANT TRAZODONE IN THE TREATMENT OF ALCOHOLISM: AN OPEN STUDY
Janiri, L., Hadjichristos, A., BUONANNO, A., Rago, R., Mannelli, P., & Risio, S. D. (1998) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008405 · Cited by 28
Dopaminergic and opiate agonists and antagonists differentially decrease multiple schedule responding maintained by sucrose/ethanol and sucrose
Slawecki, C. J., Hodge, C. W., & Samson, H. H. (1997) · Alcohol · doi:10.1016/s0741-8329(96)00153-x · Cited by 28
Naltrexone in the treatment of male alcoholics - an effectiveness study in Singapore
Lee, A. M., Tan, S., Lim, D., Winslow, R. M., Wong, K. E., Allen, J., Hall, W., & Parker, G. B. (2001) · Drug and Alcohol Review · doi:10.1080/09595230124192 · Cited by 28
High-Dose Naltrexone and Liver Function Safety
Marrazzi, M. A., Wroblewski, J. M., Kinzie, J. L., & Luby, E. D. (1997) · American Journal on Addictions · doi:10.3109/10550499708993159 · Cited by 28
Preventing incubation of drug craving to treat drug relapse: from bench to bedside
Liu, X., Yuan, K., Lu, T., Lin, X., Zheng, W., Xue, Y.-X., Shi, J., Lü, L., & Han, Y. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01942-2 · Cited by 28
Adoption of Medications in Substance Abuse Treatment: Priorities and Strategies of Single State Authorities
Rieckmann, T. R., Kovas, A. E., & Rutkowski, B. A. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400546 · Cited by 27
Liver Diseases by Alcohol and Hepatitis C: Early Detection and New Insights in Pathogenesis Lead to Improved Treatment
LIEBER, C. S. (2001) · American Journal on Addictions · doi:10.1080/10550490150504128 · Cited by 27
The effect of antagonists selective for μ- and δ-opioid receptor subtypes on alcohol consumption in C57BL/6 mice
Kim, S.-G., Stromberg, M. F., Kim, M.-J., Volpicelli, J. R., & Park, J. (2000) · Alcohol · doi:10.1016/s0741-8329(00)00109-9 · Cited by 27
Self-citation
[3H]DPDPE binding to δ opioid receptors in the rat mesocorticolimbic and nigrostriatal pathways is transiently increased by acute ethanol administration
Méndez, M., Morales‐Mulia, M., & Leriche, M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.010 · Cited by 27
Evidence-Based Treatment of Geriatric Substance Abuse
Oslin, D. W. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2005.09.005 · Cited by 27
Alcohol Dependence: The Impact of Cognitive Behaviour Therapy with or Without Naltrexone on Subjective Health Status
Feeney, G. F. X., Feeney, G. F. X., Connor, J. P., Young, R. M., Tucker, J., & McPherson, A. (2004) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2004.01469.x · Cited by 27
CSF Monoamine Metabolite and Beta Endorphin Levels in Recently Detoxified Alcoholics and Healthy Controls: Prediction of Alcohol Cue‐Induced Craving?
Petrakis, I. L., Trevisan, L. A., D’Souza, C., Gil, R. B., Krasnicki, S., Webb, E., Heninger, G. R., Cooney, N. L., & Krystal, J. H. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04355.x · Cited by 27
Naltrexone and brief counseling to reduce heavy drinking in hazardous drinkers
Davidson, D., Saha, C., Scifres, S. L., Daggy, J., O’Connor, S., & Selzer, C. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.03.027 · Cited by 27
Volitional consumption of ethanol by fawn-hooded rats: Effects of alternative solutions and drug treatments
McMillen, B. A., & Williams, H. L. (1995) · Alcohol · doi:10.1016/0741-8329(95)00015-j · Cited by 27
Treatment of alcoholism as a chronic disorder
O’Brien, C. P. (1994) · Alcohol · doi:10.1016/0741-8329(94)90063-9 · Cited by 27
Dual Diagnosis in Patients with Schizophrenia
Soyka, M. (1996) · CNS Drugs · doi:10.2165/00023210-199605060-00002 · Cited by 27
Naltrexone in alcohol dependence
Volpicelli, J. R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91316-5 · Cited by 27
Self-citation
The Subchronic Effects of the TRH Analog TA‐0910 and Bromocriptine on Alcohol Preference in Alcohol‐Preferring Rats: Development of Tolerance and Cross‐Tolerance
Mason, G., Rezvani, A. H., Grady, D. R., & Garbutt, J. C. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00104.x · Cited by 27
NEUROBEHAVIOURAL BASIS FOR THE PHARMACOTHERAPY OF ALCOHOLISM: CURRENT AND FUTURE DIRECTIONS
Anton, R. F. (1996) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008217 · Cited by 27
Overview of Pharmacologic Treatment Approaches for Alcohol and Other Drug Addiction: Intoxication, Withdrawal, and Relapse Prevention
Gorelick, D. A. (1993) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30197-7 · Cited by 27
Counselor attitudes toward the use of naltrexone in substance abuse treatment: A multi-level modeling approach
Abraham, A. J., Rieckmann, T. R., McNulty, T. L., Kovas, A. E., & Roman, P. M. (2011) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.01.030 · Cited by 26
Naltrexone: A History and Future Directions.
Srivastava, A. B., & Gold, M. S. (2018) · Europe PMC (PubMed Central) · Cited by 26
Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics
Sarkisyan, D., Hussain, M. Z., Watanabe, H., Kononenko, O., Bazov, I., Zhou, X., Yamskova, О. V., Krishtal, O., Karpyak, V. M., Yakovleva, T., et al. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00187 · Cited by 26
Pharmacotherapy of Alcohol Use Disorders and Concurrent Psychiatric Disorders: A Review
Lev‐Ran, S., Balchand, K., Lefebvre, L. G., Araki, K. F., & Foll, B. L. (2012) · The Canadian Journal of Psychiatry · doi:10.1177/070674371205700603 · Cited by 27
Predictors for the Efficacy of Naltrexone Treatment in Alcohol Dependence: Sweet Preference
Лааксонен, Э., Lahti, J. M. T., Sinclair, J. D., Heinälä, P., & Alho, H. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agq101 · Cited by 26
In vivo evaluation of a transdermal codrug of 6-β-naltrexol linked to hydroxybupropion in hairless guinea pigs
Kiptoo, P. K., Paudel, K. S., Hammell, D. C., Hamad, M. O., Crooks, P. A., & Stinchcomb, A. L. (2008) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2008.01.006 · Cited by 26
Ethanol-induced effects on opioid peptides in adult male Wistar rats are dependent on early environmental factors
Gustafsson, L., Zhou, Q., & Nylander, I. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.037 · Cited by 28
Naltrexone Selectively Elevates GABAergic Neuroactive Steroid Levels in Heavy Drinkers With the ASP40 Allele of the OPRM1 Gene: A Pilot Investigation
Ray, L. A., Hutchison, K. E., Ashenhurst, J. R., & Morrow, A. L. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01233.x · Cited by 24
The acquisition and maintenance of voluntary ethanol drinking in the rat: effects of dopaminergic lesions and naloxone
Shoemaker, W. J., Vavrousek-Jakuba, E., Arons, C., & Kwok, F.-C. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00290-5 · Cited by 26
Postoperative analgesia in patients with substance use disorders: Part II
Jage, J., & Bey, T. A. (2000) · Acute Pain · doi:10.1016/s1366-0071(00)80021-2 · Cited by 25
Rationale for combining acamprosate and naltrexone for treating alcohol dependence.
Mason, B. J. (2005) · Journal of Studies on Alcohol Supplement · doi:10.15288/jsas.2005.s15.148 · Cited by 26
Phenytoin in the treatment of cocaine abuse: A double-blind study*
Crosby, R. D., Pearson, V. L., Eller, C., Winegarden, T., & Graves, N. L. (1996) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(96)90116-2 · Cited by 26
A Review of Pharmacotherapie for Substance Abuse
Kosten, T. R., & McCance, E. F. (1996) · American Journal on Addictions · doi:10.3109/10550499608995657 · Cited by 26
CURRENT CONCEPTS IN THE TREATMENT OF DEPRESSION IN ALCOHOL-DEPENDENT PATIENTS
McGrath, P. J., Nunes, E. V., & Quitkin, F. M. (2000) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70192-1 · Cited by 26
What the alcohol doctor ordered from the neuroscientist
Heilig, M., & Leggio, L. (2016) · Progress in Brain Research · doi:10.1016/bs.pbr.2015.07.023 · Cited by 25
Naltrexone attenuates amphetamine-induced locomotor sensitization in the rat
Häggkvist, J., Björkholm, C., Steensland, P., Lindholm, S., Franck, J., & Schilström, B. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00199.x · Cited by 25
Sudden unexpected death in epilepsy
Duble, S. N., & Thomas, S. V. (2017) · The Indian Journal of Medical Research · doi:10.4103/ijmr.ijmr_548_17 · Cited by 25
Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook
Singh, L., Joshi, T., Tewari, D., Echeverría, J., Mocan, A., Sah, A. N., Parvanov, E. D., Tzvetkov, N. T., Feei, Z., Lee, Y. Y., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01593 · Cited by 26
Appetitive motivational experience during adolescence results in enhanced alcohol consumption during adulthood.
Walker, B. M., & Ehlers, C. L. (2009) · Behavioral Neuroscience · doi:10.1037/a0016002 · Cited by 27
Effect of topical naltrexone 0.3% on corneal sensitivity and tear parameters in normal brachycephalic dogs
Arnold, T. S., Wittenburg, L. A., & Powell, C. C. (2013) · Veterinary Ophthalmology · doi:10.1111/vop.12079 · Cited by 25
Development and validation of a liquid chromatography–mass spectrometry method for the quantitation of naltrexone and 6β-naltrexol in guinea pig plasma
Valiveti, S., Nalluri, B. N., Hammell, D. C., Paudel, K. S., & Stinchcomb, A. L. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.08.016 · Cited by 25
Further Validation of the Obsessive‐Compulsive Drinking Scale (OCDS)
Moak, D. H., Anton, R. F., & Latham, P. K. (1998) · American Journal on Addictions · doi:10.1111/j.1521-0391.1998.tb00463.x · Cited by 25

Authors: Volpicelli, J. R.
Affiliations: University of Pennsylvania (US)
Corresponding author: Volpicelli, Joseph R.
ORCID: Volpicelli, Joseph R.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 1992-11-01
Volume: 49
Issue: 11
Pages: 876
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.1992.01820110040006
OpenAlex: W2104538950
Cited by: 1,828
References: 23
Citations by year: 2026: 7 · 2025: 10 · 2024: 17 · 2023: 15 · 2022: 25 · 2021: 17 · 2020: 28 · 2019: 26 · 2018: 29 · 2017: 26 · 2016: 32 · 2015: 48 · 2014: 49 · 2013: 47 · 2012: 58
FWCI: 36.57
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA0751701A1)
National Institute on Drug Abuse (DA-05186)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
Keywords: naltrexone, alcoholism, alcohol craving, alcohol relapse prevention, alcohol detoxification, outpatient care, opioid antagonists, adjunct pharmacotherapy, nausea, arthritic pain
MeSH terms: Adult, Alcohol Drinking, Alcoholism, Ambulatory Care, Combined Modality Therapy, Double-Blind Method, Humans, Male, Naltrexone, Nausea, Patient Dropouts, Placebos, Psychiatric Status Rating Scales, Psychotherapy, Recurrence, Severity of Illness Index, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Naltrexone in the Treatment of Alcohol Dependence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks