The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Frontostriatal Disorder of Cerebral Metabolism in Never-Medicated Schizophrenics
Abstract
We scanned 18 patients with schizophrenia who had never received neuroleptic medication and 20 age- and sex-matched controls by positron emission tomography with 18-F-fluorodeoxyglucose (fludeoxyglucose F 18) as a tracer of glucose metabolism. Subjects performed the Continuous Performance Test during 18-F-fluorodeoxyglucose uptake. Scan results were converted to metabolic rates, and computer algorithms were used to identify cortical regions. Previous reports of relative hypofrontality in schizophrenia were confirmed, indicating that this finding is not an artifact of previous treatment. Significantly reduced ratios of inferior and medial frontal regions to occipital cortex were found, together with diminished metabolism in the basal ganglia. This suggests the presence of a combined frontostriatal dysfunction in schizophrenia.
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Citations
Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Cornblatt, B. A., Risch, N. J., Faris, G., Friedman, D., & Erlenmeyer-Kimling, L. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90076-5 · Cited by 682
Cited by
Basal ganglia and cerebellar loops: motor and cognitive circuits
Middleton, F. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00040-5 · Cited by 1,940
Andreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Ponto, L. L., Watkins, G. L., & Hichwa, R. D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9985 · Cited by 625
Increased cortical kynurenate content in schizophrenia
Schwarcz, R., Rassoulpour, A., Wu, H.-Q., Medoff, D., Tamminga, C. A., & Roberts, R. C. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01078-2 · Cited by 590
Keshavan, M. S., Anderson, S., & Pettergrew, J. W. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90009-4 · Cited by 525
Neuroimaging studies of the hippocampus in schizophrenia
Heckers, S. (2001) · Hippocampus · doi:10.1002/hipo.1068 · Cited by 420
Metadata
- Authors
- Buchsbaum, M. S.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1992-12-01
- Volume
- 49
- Issue
- 12
- Pages
- 935
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2103248466
- Cited by
- 324
- References
- 2
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- closed
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