Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry
Open accessAbstract
Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental activities. Working interactively with the prefrontal cortex, the cerebellum may play a role in coordinating both motor and cognitive performance. This positron-emission tomography study suggests the presence of a prefrontal-thalamic-cerebellar network that is activated when normal subjects recall complex narrative material, but is dysfunctional in schizophrenic patients when they perform the same task. These results support a role for the cerebellum in cognitive functions and suggest that patients with schizophrenia may suffer from a "cognitive dysmetria" due to dysfunctional prefrontal-thalamic-cerebellar circuitry.
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CBM-iTBS has demonstrated benefits for psychiatric conditions such as schizophrenia.
“Noninvasive stimulation of the cerebellum with transcranial magnetic stimulation (TMS), specifically posterior cerebellum-targeted intermittent theta burst stimulation (CBM-iTBS), has demonstrated benefits for psychiatric conditions, such as schizophrenia, which manifest potentially cerebellum-mediated symptoms including mood dysregulation and cognitive dysmetria (Andreasen, 1999; Andreasen et al.”
From A double-blind, randomized, sham-controlled clinical trial of cerebellar intermittent theta burst stimulation for bipolar disorder: Safety, tolerability, mood and cognitive effects (2025) · cites this paper as Andreasen et al., 1996
The PET study’s Conclusions and Implications (page unavailable) link schizophrenia to abnormalities in prefrontal–thalamic–cerebellar circuitry and cognitive dysmetria. It does not study TMS or CBM-iTBS, so it cannot support the claim that this stimulation has demonstrated benefits for schizophrenia. (LLM, conf=0.86)
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- Authors
- Andreasen, N. C., O'Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Ponto, L. L., Watkins, G. L., & Hichwa, R. D.
- Affiliations
- University of Iowa (US)
- Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USA.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1996-09-03
- Volume
- 93
- Issue
- 18
- Pages
- 9985-9990
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC38542
- OpenAlex
- W2014387288
- Cited by
- 625
- References
- 2
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 15 · 2023: 9 · 2022: 14 · 2021: 26 · 2020: 13 · 2019: 16 · 2018: 24 · 2017: 17 · 2016: 14 · 2015: 21 · 2014: 22 · 2013: 27 · 2012: 16
- FWCI
- 16.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 40856, MH-31593, MHCRC-43271, R01MH040856)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- schizophrenia, cognitive dysmetria, cerebellum, prefrontal cortex, thalamus, narrative recall, cognitive coordination, cerebellar cognitive function
- MeSH terms
- Adult, Cerebellum, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Radiography, Schizophrenia, Thalamus, Tomography, Emission-Computed, Prefrontal Cortex
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