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Negative Symptoms and Hypofrontality in Chronic Schizophrenia
Abstract
Frontal lobe dysfunction is widely suspected to underlie negative symptoms of schizophrenia. This hypothesis is based largely on long-standing observations of the similarities between the effects of frontal lobe lesions and negative symptoms. However, there is little direct evidence specifically for such an association in schizophrenic patients. We measured the relationship between decreased relative prefrontal cortex glucose metabolism (hypofrontality) using positron emission tomography and evaluated the severity of negative symptoms in 20 chronic schizophrenics who underwent scanning while not receiving neuroleptic drugs. We found a close relationship between negative symptoms and prefrontal hypometabolism, particularly in the right dorsolateral convexity. This association was regionally specific. Furthermore, there was no evidence that this relationship was an artifact of age, cerebral atrophy, or severity of positive symptoms.
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Cites
Neuropsychological studies of the frontal lobes.
Stuss, D. T., & Benson, D. F. (1984) · Psychological Bulletin · doi:10.1037/0033-2909.95.1.3 · Cited by 1,073
Cited by
Keshavan, M. S., Anderson, S., & Pettergrew, J. W. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90009-4 · Cited by 525
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.6.805 · Cited by 392
Sanfilipo, M., Lafargue, T., Rusinek, H., Arena, L., Loneragan, C., Lautin, A., Feiner, D., Rotrosen, J., & Wolkin, A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.471 · Cited by 281
Self-citationGouzoulis-Mayfrank, E. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00089-x · Cited by 219
Weakened center-surround interactions in visual motion processing in schizophrenia
Tadin, D., Kim, J., Doop, M. L., Gibson, C., Lappin, J. S., Blake, R., & Park, S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2592-06.2006 · Cited by 182
Metadata
- Authors
- Wolkin, A.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1992-12-01
- Volume
- 49
- Issue
- 12
- Pages
- 959
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2023734494
- Cited by
- 393
- References
- 1
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
