The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Neuroleptic Withdrawal in Schizophrenic Patients: A Review of the Literature
Abstract
In the treatment of chronic schizophrenia, there are risks associated with both neuroleptic maintenance (eg, tardive dyskinesia) and neuroleptic withdrawal (eg, psychotic exacerbation or relapse). We reviewed 66 studies on neuroleptic withdrawal involving 4365 patients with schizophrenia. The mean cumulative relapse rate was 53% in patients withdrawn from neuroleptic therapy and 16% in those maintained on neuroleptic therapy over a mean follow-up period of 9.7 months. The relapse rate was positively associated with length of follow-up. Predictors of relapse reported in individual studies included younger age, higher baseline neuroleptic dosage, and shorter length of hospitalization. Adverse effects of neuroleptic withdrawal other than relapse were usually mild and transient. The risk-benefit ratio of neuroleptic maintenance vs withdrawal should be assessed carefully in individual patients. A slow taper to the lowest effective dosage may be the preferred strategy in many patients.
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Cites
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Neuroleptics and the Natural Course of Schizophrenia
Wyatt, R. J. (1991) · Schizophrenia Bulletin · doi:10.1093/schbul/17.2.325 · Cited by 787
Predictors of improvement in tardive dyskinesia following discontinuation of neuroleptic medication
Glazer, W. M., Morgenstern, H., Schooler, N., Berkman, C. S., & Moore, D. C. (1990) · British Journal of Psychiatry · doi:10.1192/bjp.157.4.585 · Cited by 106
Neylan, T. C. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080051008 · Cited by 69
Cited by
Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813
Leucht, S., Tardy, M., Komossa, K., Heres, S., Kissling, W., Salanti, G., & Davis, J. M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60239-6 · Cited by 931
Barnes, T. R., Drake, R., Paton, C., Cooper, S. J., Deakin, B., Ferrier, I. N., Gregory, C. J., Haddad, P. M., Howes, O. D., Jones, I., et al. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881119889296 · Cited by 606
Wunderink, L., Nieboer, R. M., Wiersma, D., Sytema, S., & Nienhuis, F. J. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.19 · Cited by 567
From dopamine to salience to psychosis—Linking biology, pharmacology and phenomenology of psychosis
Kapur, S., Mizrahi, R., & Li, M. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.01.003 · Cited by 512
Metadata
- Authors
- Gilbert, P. L.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1995-03-01
- Volume
- 52
- Issue
- 3
- Pages
- 173
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1983341781
- Cited by
- 435
- References
- 4
- FWCI
- 20.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gilbert, P. L. (1995). Neuroleptic Withdrawal in Schizophrenic Patients: A Review of the Literature. Archives of General Psychiatry. https://doi.org/10.1001/archpsyc.1995.03950150005001
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