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Cited by 787Schizophrenia research and treatmentMental Health and PsychiatryBipolar Disorder and Treatment

Neuroleptics and the Natural Course of Schizophrenia

Wyatt, R. J.·1991·Schizophrenia Bulletin
DOI 10.1093/schbul/17.2.325
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Abstract

To determine if neuroleptic treatment changes the natural course of schizophrenia, 22 studies were reviewed in which relatively similar patients were or were not given neuroleptics at specific times during the course of their illness. Nineteen of the studies were from first- or predominantly first-break populations. While there was little consensus among the authors of the studies reviewed, a reanalysis of the data indicates that early intervention with neuroleptics in first-break schizophrenic patients increases the likelihood of an improved long-term course. This finding is similar to that of earlier investigators who indicated there was a decrease in patients with the more severe forms of the illness following the introduction of convulsive therapies. Furthermore, there is evidence that stable schizophrenic patients whose neuroleptics are discontinued and have relapses may have a difficult time returning to their previous level of function. The findings describe in this paper have implications for both the treatment of schizophrenia and for understanding the pathophysiological processes that determine the course of the disorder.

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Crossref · 10.1093/schbul/17.2.325

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73 of 73 references verified0 citation errors · 0 not checkable

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  • Schizophrenia pathology worsens over time, as supported by studies suggesting that long-term morbidity increases in the absence of any treatment.

    “The notion that schizophrenia pathology worsen over time is supported by studies that suggest that long-term morbidity increases in the absence of any treatment 45,46 .”

    From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [45]

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Authors
Wyatt, R. J.
Affiliations
St. Elizabeths Hospital (US)
Corresponding author
Wyatt, R. J.
Venue
Schizophrenia Bulletin
Publisher
Oxford University Press (OUP)
Published
1991-01-01
Volume
17
Issue
2
Pages
325-351
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
DOI
10.1093/schbul/17.2.325
OpenAlex
W2120012268
Cited by
787
References
73
Citations by year
2026: 6 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 21 · 2020: 12 · 2019: 48 · 2018: 14 · 2017: 18 · 2016: 17 · 2015: 17 · 2014: 18 · 2013: 22 · 2012: 27
FWCI
13.18
Type
journal article
Language
en
Open access
closed
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
schizophrenia, antipsychotic drugs
MeSH terms
Humans, Recurrence, Schizophrenia, Time Factors, Antipsychotic Agents

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