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Cited by 1,056Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchMemory Processes and Influences

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

A Symptom Provocation Study of Posttraumatic Stress Disorder Using Positron Emission Tomography and Script-Driven Imagery

Rauch, Scott L.·1996·Archives of General Psychiatry
DOI 10.1001/archpsyc.1996.01830050014003
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Abstract

BACKGROUND: Previous studies have used symptom provocation and positron emission tomography to delineate the brain systems that mediate various anxiety states. Using an analogous approach, the goal of this study was to measure regional cerebral blood flow changes associated with posttraumatic stress disorder (PTSD) symptoms. METHODS: Eight patients with PTSD, screened as physiologically responsive to a script-driven imagery symptom provocation paradigm, were exposed sequentially to audiotaped traumatic and neutral scripts in conjunction with positron emission tomography. Heart rate and subjective measures of emotional state were obtained for each condition. Statistical mapping techniques were used to determine locations of significant brain activation. RESULTS: Increases in normalized blood flow were found for the traumatic as compared with control conditions in right-sided limbic, paralimbic, and visual areas; decreases were found in left inferior frontal and middle temporal cortex. CONCLUSIONS: The results suggest that emotions associated with the PTSD symptomatic state are mediated by the limbic and paralimbic systems within the right hemisphere. Activation of visual cortex may correspond to the visual component of PTSD reexperiencing phenomena.

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Crossref · 10.1001/archpsyc.1996.01830050014003

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Metadata

Authors
Rauch, S. L.
Affiliations
Harvard University (US)
Corresponding author
Rauch, Scott L.
ORCID
Rauch, Scott L.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1996-05-01
Volume
53
Issue
5
Pages
380
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1996.01830050014003
OpenAlex
W2031636627
Semantic Scholar
0bfd5b1f356a3b03fd76b7a3f2aa8f7143186072
Cited by
1,056
References
55
Citations by year
2026: 12 · 2025: 47 · 2024: 13 · 2023: 20 · 2022: 23 · 2021: 20 · 2020: 22 · 2019: 29 · 2018: 17 · 2017: 16 · 2016: 36 · 2015: 28 · 2014: 22 · 2013: 25 · 2012: 28
FWCI
52.09
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k20mh001215-05, 5r01mh048559-02)
  • National Institute of Mental Health (MH01215, MH-48559)
  • National Cancer Institute (5T32CA09362, T32CA009362)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
post-traumatic stress disorder, symptom provocation, script-driven imagery, regional cerebral blood flow, limbic system, paralimbic system, right hemisphere, re-experiencing, visual cortex, emotional state, heart rate
MeSH terms
Adult, Brain, Cerebrovascular Circulation, Emotions, Female, Frontal Lobe, Heart Rate, Humans, Imagination, Functional Laterality, Life Change Events, Limbic System, Male, Memory, Middle Aged, Regional Blood Flow, Stress Disorders, Post-Traumatic, Tomography, Emission-Computed, Visual Cortex

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