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Cited by 243Bipolar Disorder and TreatmentSchizophrenia research and treatmentTreatment of Major Depression

Second-Generation Antipsychotic Agents in the Treatment of Acute Mania: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Scherk, Harald, Pajonk, Frank Gerald, Leucht, Stefan·2007·Archives of General Psychiatry
DOI 10.1001/archpsyc.64.4.442
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Abstract

Context Recommendations of treatment guidelines concerning the use of second-generation antipsychotic (SGA) agents for acute mania vary substantially across committees or working groups. Meta-analyses addressing the use of SGAs in the treatment of acute mania are lacking. Objective To conduct a meta-analysis of the efficacy and safety of SGAs in the treatment of acute mania. Data sources Randomized controlled trials comparing SGAs with placebo, first-generation antipsychotic drugs, or mood stabilizers (MSs) in the treatment of acute mania were searched for in the PsiTri and MEDLINE databases (last search: May 2006). Study selection The abstracts, titles, and index terms of studies were searched using the following key words: aripiprazole, amisulpride, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, and zotepine in conjunction with mania, manic, and bipolar. Data extraction Data on efficacy, global dropout, dropout due to adverse events, dropout due to inefficacy, weight gain, rate of somnolence, and extrapyramidal symptoms were extracted and combined in a meta-analysis. Data synthesis A total of 24 studies with 6187 patients were included. The SGAs were significantly more efficacious than placebo. The analysis demonstrated that adding antipsychotic agents to MS treatment was significantly more effective than treatment with MSs alone. The SGAs displayed efficacy comparable with that of MSs. Some SGAs seemed to induce more extrapyramidal symptoms than placebo. The…

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  • Combining atypical antipsychotics and mood stabilizers is the most efficacious treatment in acute mania.

    “Currently available data suggest that combining atypical antipsychotics and mood stabilizers is the most efficacious treatment in acute mania, reinforced after a systematic review and meta-analysis of pooled data conducted by Perlis and Scherk”

    From Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis (2010) · cites this paper as Scherk et al. 2007

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Authors
Scherk, H., Pajonk, F. G., & Leucht, S.
Affiliations
University of Göttingen (DE)
ORCID
Leucht, Stefan
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
2007-04-01
Volume
64
Issue
4
Pages
442
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.64.4.442
OpenAlex
W2145830637
Cited by
243
References
5
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 3 · 2016: 11 · 2015: 13 · 2014: 13 · 2013: 15 · 2012: 23
FWCI
19.13
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
  • GRO (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
atypical antipsychotics, acute mania, bipolar disorder, aripiprazole, amisulpride, clozapine, olanzapine, quetiapine, risperidone, ziprasidone, zotepine, mood stabilizers, combination therapy, extrapyramidal symptoms, sleepiness, weight gain, treatment efficacy, drug safety
MeSH terms
Acute Disease, Adult, Anticonvulsants, Basal Ganglia Diseases, Bipolar Disorder, Drug Therapy, Combination, Humans, Patient Dropouts, Placebos, Sleep Wake Disorders, Antipsychotic Agents, Randomized Controlled Trials as Topic, Treatment Outcome, Lithium Compounds

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