Striatal structure and function in mood disorders: a comprehensive review

Marchand, William R; Yurgelun‐Todd, Deborah

doi:10.1111/j.1399-5618.2010.00874.x

Cited by 91Bipolar Disorder and TreatmentNeural and Behavioral Psychology StudiesTreatment of Major Depression

Striatal structure and function in mood disorders: a comprehensive review

Marchand, William R, Yurgelun‐Todd, Deborah·2010·Bipolar Disorders

DOI 10.1111/j.1399-5618.2010.00874.x

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Abstract

Marchand WR, Yurgelun‐Todd D. Striatal structure and function in mood disorders: a comprehensive review. Bipolar Disord 2010: 12: 764–785. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objectives: A large and diverse literature has implicated abnormalities of striatal structure and function in both unipolar and bipolar disorder. Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature. Methods: A total of 331 relevant articles were reviewed to develop an integrated overview of striatal function in mood disorders. Results: There is compelling evidence from multiple studies that functional abnormalities of the striatum and greater corticostriatal circuitry exist in at least some forms of affective illness. The literature does not yet provide data to determine whether these aberrations represent primary pathology or they contribute directly to symptom expression. Finally, there is considerable evidence that bipolar disorder may be associated with striatal hyperactivity and some suggestion that unipolar illness may be associated with hypoactivation. Conclusions: Additional research investigating striatal function in affective disorders will be critical to the development of comprehensive models of the neurobiology of these conditions.

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Evidence for abnormalities in reward-related neural network function in mania is scarce.
“Although functional MRI studies have identified prefrontal dysfunction in bipolar disorder and manic psychosis, evidence for abnormalities in reward-related neural network function in mania is scarce [271-275].”
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Rosenberg, D. R., MacMaster, F. P., Mirza, Y., Smith, J. M., Easter, P. C., Banerjee, S. P., Bhandari, R. P., Boyd, C. C., Lynch, M. A., Rose, M., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.007 · Cited by 137 · see citing works
Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events
Apicella, P. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02262.x · Cited by 134 · see citing works
Chronic, treatment-resistant depression and right fronto-striatal atrophy
Shah, P. J., Glabus, M. F., Goodwin, G. M., & Ebmeier, K. P. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.5.434 · Cited by 134 · see citing works
Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression
Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01089-7 · Cited by 133 · see citing works
The effect of chronic fluoxetine on social isolation-induced changes on sucrose consumption, immobility behavior, and on serotonin and dopamine function in hippocampus and ventral striatum
Brenes, J. C., & Fornaguera, J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.036 · Cited by 132 · see citing works
An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder
Caligiuri, M. P., Brown, G. G., Meloy, M. J., Eberson, S., Kindermann, S. S., Frank, L. R., Zorrilla, L. T. E., & Lohr, J. B. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00075-1 · Cited by 130 · see citing works
Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder
Kalmar, J. H., Wang, F. “., Chepenik, L. G., Womer, F. Y., Jones, M. M., Pittman, B. P., Shah, M. P., Martin, A., Constable, R. T., & Blumberg, H. P. (2009) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31819f6fbc · Cited by 130 · see citing works
Magnetic-resonance morphometry in patients with major depression
Parashos, I. A., Tupler, L. A., Blitchington, T. F., & Krishnan, K. (1998) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(98)00042-0 · Cited by 130 · see citing works
Volume deficits of subcortical nuclei in mood disorders
Bielau, H., Trübner, K., Krell, D., Agelink, M. W., Bernstein, H., Stauch, R., Mawrin, C., Dános, P., Gerhard, L., Bogerts, B., et al. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0581-y · Cited by 129 · see citing works
Pramipexole in Psychiatry
Aiken, C. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0810 · Cited by 129 · see citing works
Reduced Anterior Cingulate Cortex Glutamatergic Concentrations in Childhood Major Depression
Mirza, Y., Tang, J., Russell, A., Banerjee, S. P., Bhandari, R. P., Ivey, J., Rose, M., Moore, G. J., & Rosenberg, D. R. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200403000-00017 · Cited by 128 · see citing works
Changes in brain metabolism associated with remission in unipolar major depression
Holthoff‐Detto, V., Beuthien‐Baumann, B., Zündorf, G., Triemer, A., Lüdecke, S., Winiecki, P., Koch, R., Füchtner, F., & Herholz, K. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2004.00351.x · Cited by 127 · see citing works
Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
Feyissa, A. M., Woolverton, W. L., Miguel-Hidalgo, J. J., Wang, Z., Kyle, P. B., Hasler, G., Stockmeier, C. A., Iyo, A. H., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.018 · Cited by 126 · see citing works
Dopamine D2 receptor binding before and after treatment of major depression measured by [123I]IBZM SPECT
Klimke, A. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00009-8 · Cited by 126 · see citing works
Regional Cerebral Glucose Metabolic Abnormalities in Bipolar II Depression
Mah, L., Zarate, C. A., Singh, J. B., Duan, Y.-F., Luckenbaugh, D. A., Manji, H. K., & Drevets, W. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.009 · Cited by 125 · see citing works
The associative striatum: Organization of cortical projections to the dorsocentral striatum in rats
Reep, R. L., Cheatwood, J. L., & Corwin, J. V. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10868 · Cited by 125 · see citing works
Reduced activation to implicit affect induction in euthymic bipolar patients: An fMRI study
Malhi, G. S., Lagopoulos, J., Owen, A. M., Ivanovski, B., Shnier, R., & Sachdev, P. S. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.06.005 · Cited by 122 · see citing works
Markers of Glutamate Synaptic Transmission and Plasticity Are Increased in the Anterior Cingulate Cortex in Bipolar Disorder
Eastwood, S. L., & Harrison, P. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.004 · Cited by 122 · see citing works
PET Study of [18F]6-Fluoro-<scp>l</scp>-Dopa Uptake in Neuroleptic- and Mood-Stabilizer-Naive First-Episode Nonpsychotic Mania: Effects of Treatment With Divalproex Sodium
Yatham, L. N., Liddle, P. F., Shiah, I.-S., Lam, R. W., Ngan, E., Scarrow, G., Imperial, M., Stoessl, J., Sossi, V., & Ruth, T. J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.768 · Cited by 122 · see citing works
Anatomical MRI study of basal ganglia in major depressive disorder
Lacerda, A. L. T., Nicoletti, M., Brambilla, P., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00123-9 · Cited by 121 · see citing works
Gap Junctions between Striatal Fast-Spiking Interneurons Regulate Spiking Activity and Synchronization as a Function of Cortical Activity
Hjorth, J. J. J., Blackwell, K. T., & Kotaleski, J. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6031-08.2009 · Cited by 118 · see citing works
Quantification of Neuroreceptors in the Living Human Brain: IV. Effect of Aging and Elevations of D 2 -Like Receptors in Schizophrenia and Bipolar Illness
Wong, D. F., Pearlson, G. D., Tune, L. E., Young, L. T., Meltzer, C. C., Dannals, R. F., Ravert, H. T., Reith, J., Kuhar, M. J., & Gjedde, A. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199703000-00010 · Cited by 118 · see citing works
Transient Depressive Relapse Induced by Catecholamine Depletion
Berman, R., Narasimhan, M., Miller, H., Anand, A., Cappiello, A., Oren, D. A., Heninger, G. R., & Charney, D. S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.5.395 · Cited by 118 · see citing works
Responses of Tonically Active Neurons in the Monkey Striatum Discriminate between Motivationally Opposing Stimuli
Ravel, S., Legallet, E., & Apicella, P. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-24-08489.2003 · Cited by 116 · see citing works
Beauty in the Brain of the Beholder
Senior, C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00293-9 · Cited by 115 · see citing works
Bipolar affective disorder
Dewan, M. J., Haldipur, C. V., Lane, E., Ispahani, A., Boucher, M. F., & Major, L. F. (1988) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1988.tb05186.x · Cited by 113 · see citing works
Reduced Muscarinic Type 2 Receptor Binding in Subjects With Bipolar Disorder
Cannon, D. M., Carson, R. E., Nugent, A. C., Eckelman, W. C., Kiesewetter, D. O., Williams, J., Rollis, D., Drevets, M., Gandhi, S. K., Solorio, G., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.741 · Cited by 110 · see citing works
Identification of catecholaminergic inputs to and outputs from aromatase-containing brain areas of the Japanese quail by tract tracing combined with tyrosine hydroxylase immunocytochemistry
Balthazart, J., & Absil, P. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970609)382:3 · Cited by 110 · see citing works
Anatomical MRI study of basal ganglia in bipolar disorder patients
Brambilla, P., Harenski, K. A., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2001) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(01)00073-7 · Cited by 109 · see citing works

Flagged first, then by citations

Sorted by citations

Cognitive impairment in euthymic major depressive disorder: a meta-analysis
Bora, E., Harrison, B. J., Yücel, M., & Pantelis, C. (2013) · Psychological Medicine · doi:10.1017/s0033291712002085 · Cited by 551 · see citing works
“These pronounced deficits might be related to progressive abnormalities in cortico-striatal-pallidal-thalamic circuits that have been identified in MDD (Rogers et al. 1998 ; Marchand & Yurgelun-Todd, 2010; Bora et al. 2012b) as well as vascular changes in white matter (Herrmann et al. 2008).”
Background
The functional neuroanatomy of bipolar disorder: a consensus model
Strakowski, S. M., Adler, C. M., Almeida, J., Altshuler, L. L., Blumberg, H. P., Chang, K., DelBello, M. P., Frangou, S., McIntosh, A. M., Phillips, M. L., et al. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01022.x · Cited by 540 · see citing works
“Marchand WR, Yurgelun-Todd D. Striatal structure and function in mood disorders: a comprehensive review.”
ResultInfluential
Mindfulness-based stress reduction, mindfulness-based cognitive therapy, and zen meditation for depression, anxiety, pain, and psychological distress.
MARCHAND, W. R. (2012) · Journal of Psychiatric Practice® · doi:10.1097/01.pra.0000416014.53215.86 · Cited by 305 · see citing works
Self-citation
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
“Although functional MRI studies have identified prefrontal dysfunction in bipolar disorder and manic psychosis, evidence for abnormalities in reward-related neural network function in mania is scarce [271-275].”
Background
Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorder
Bora, E., Harrison, B. J., Davey, C. G., Yücel, M., & Pantelis, C. (2012) · Psychological Medicine · doi:10.1017/s0033291711001668 · Cited by 276 · see citing works
“…imaging (MRI) has been widely used to examine neurobiological correlates of MDD and has provided converging evidence in support of prevailing pathophysiological models of this disorder (Mayberg et al. 1997 ; Drevets et al. 2008 ; Marchand, 2010 ; Marchand & Yurgelun-Todd, 2010 ; Pizzagalli, 2011).”
MethodResultInfluential
Mapping subcortical brain maturation during adolescence: evidence of hemisphere- and sex-specific longitudinal changes
Dennison, M., Whittle, S., Yücel, M., Vijayakumar, N., Kline, A., Simmons, J., & Allen, N. B. (2013) · Developmental Science · doi:10.1111/desc.12057 · Cited by 146 · see citing works
“…in the abnormal hedonic, behavioral and motivational functioning observed in both depression and substance use disorders (Chambers et al., 2003; Marchand & Yurgelun-Todd, 2010; Nestler & Carlezon, 2006), may contribute to understanding sex differences in the adolescent prevalence of both…”
Background
Striatal dopamine transporter availability in unmedicated bipolar disorder: Striatal DAT in unmedicated bipolar disorder
Anand, A., Barkay, G., Dzemidzic, M., Albrecht, D., Karne, H., Zheng, Q.-H., Hutchins, G. D., Normandin, M. D., & Yoder, K. K. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00936.x · Cited by 139 · see citing works
Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors
Beblo, T., Sinnamon, G., & Baune, B. T. (2011) · Neuropsychology Review · doi:10.1007/s11065-011-9171-0 · Cited by 128 · see citing works
Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study
Bouckaert, F., De Winter, F.-L., Emsell, L., Dols, A., Rhebergen, D., Wampers, M., Sunaert, S., Stek, M., Sienaert, P., & Vandenbulcke, M. (2016) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140322 · Cited by 115 · see citing works
The functional neuroanatomy of bipolar disorder
Cerullo, M. A., Adler, C. M., Delbello, M. P., & Strakowski, S. M. (2009) · International Review of Psychiatry · doi:10.1080/09540260902962107 · Cited by 113 · see citing works
Brain Network Dysfunction in Late-Life Depression
Tadayonnejad, R., & Ajilore, O. (2013) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713516539 · Cited by 114 · see citing works
Neural Activation During Facial Emotion Processing in Unmedicated Bipolar Depression, Euthymia, and Mania
Hulvershorn, L. A., Karne, H. S., Gunn, A. D., Hartwick, S. L., Wang, Y., Hummer, T. A., & Anand, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.038 · Cited by 100 · see citing works
Striatal and cortical midline circuits in major depression: Implications for suicide and symptom expression
Marchand, W. R., Lee, J. N., Johnson, S., Thatcher, J. W., Gale, P. D., Wood, N., & Jeong, E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.10.016 · Cited by 92 · see citing works
“There is extensive evidence that the function of the striatum and associated cortico-basal ganglia circuitry plays a role in the neuropathology of affective disorders, for recent reviews see Marchand (2010); Marchand and Yurgelun-Todd (2010).”
BackgroundSelf-citation
Differential Resting-State Functional Connectivity of Striatal Subregions in Bipolar Depression and Hypomania
Altinay, M. I., Hulvershorn, L. A., Karne, H. S., Beall, E. B., & Anand, A. (2015) · Brain Connectivity · doi:10.1089/brain.2015.0396 · Cited by 84 · see citing works
“In their comprehensive review, Marchand and Yurgelun-Todd (2010) reported that studies that investigated striatal activation in bipolar mania showed increased ventral striatum and caudate activity in response to motor (simple reaction time test) and emotional (alternating blocks of captioned…”
Default mode dysfunction underpins suicidal activity in mood disorders
Malhi, G. S., Das, P., Outhred, T., Bryant, R. A., Calhoun, V., & Mann, J. J. (2020) · Psychological Medicine · doi:10.1017/s0033291719001132 · Cited by 73 · see citing works
“In addition to the important role of cortical midline structures, basal ganglia dysfunction has long been implicated in mood disorders (Marchand and Yurgelun-Todd, 2010), and our finding of reduced activity in the BGN in depressed patients further substantiates this.”
Background
Somatic influences on subjective well-being and affective disorders: the convergence of thermosensory and central serotonergic systems
Raison, C. L., Hale, M. W., Williams, L. E., Wager, T. D., & Lowry, C. A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01580 · Cited by 76 · see citing works
“Increased blood flow to the skin may in turn increase personal warmth, as slight increases in facial skin redness are perceived as more attractive (Stephen et al., 2009; Re et al., 2011), in effect completing a positive feedback loop wherein interpersonal warmth promotes physical warmth, and…”
Background
Subacute Default Mode Network Dysfunction in the Prediction of Post-Stroke Depression Severity
Lassalle-Lagadec, S., Sibon, I., Dilharreguy, B., Renou, P., Fleury, O., & Michèle Allard, A. (2012) · Radiology · doi:10.1148/radiol.12111718 · Cited by 75 · see citing works
Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder
Womer, F. Y., Wang, L., Alpert, K. I., Smith, M. J., Csernansky, J. G., Barch, D. M., & Mamah, D. T. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.05.017 · Cited by 73 · see citing works
“Both these regions have been increasingly implicated in emotional and cognitive processing, particularly via cortico-basal ganglia and cortico-thalamic circuits, and appear to play important roles in executive functions that are commonly impaired in psychotic conditions (Byne et al., 2009; Haber and Calzavara, 2009; M…”
BackgroundResult
Differential effect of quetiapine and lithium on functional connectivity of the striatum in first episode mania
Dandash, O., Yücel, M., Daglas, R., Pantelis, C., McGorry, P. D., Berk, M., & Fornito, A. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0108-8 · Cited by 68 · see citing works
Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective
Yoon, S. J., Kim, T. D., Kim, J., & Lyoo, I. K. (2020) · Brain and Behavior · doi:10.1002/brb3.1953 · Cited by 67 · see citing works
A Focus on the Functions of Area 25
Alexander, L., Clarke, H. F., & Roberts, A. (2019) · Brain Sciences · doi:10.3390/brainsci9060129 · Cited by 63 · see citing works
Reward Processing in Adolescent Depression Across Neuroimaging Modalities: A Review
O’Callaghan, G., & Stringaris, A. (2019) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000663 · Cited by 63 · see citing works
“Results Functional MRI Findings Evidence from several key papers and reviews demonstrated striatal hypoactivation in unipolar depression when anticipating and consuming rewards (Barch et al., 2016; Marchand & Yurgelun-Todd, 2010).”
Background
Accelerated aging of the putamen in patients with major depressive disorder
Sacchet, M. D., Camacho, M. C., Livermore, E. E., Thomas, E. A. C., & Gotlib, I. H. (2017) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160010 · Cited by 62 · see citing works
“7 Previously research has indicated that depressed individuals have decreased activation in the striatum, 5,6 and some investigators have hypothesized that this abnormal activity affects decision-making.”
BackgroundInfluential
Deep brain stimulation for major depression
Schlaepfer, T. E., & Bewernick, B. H. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53497-2.00018-8 · Cited by 62 · see citing works
Suicidal ideation and behavior in Huntington's disease: Systematic review and recommendations
Kachian, Z. R., Cohen‐Zimerman, S., Bega, D., Gordon, B., & Grafman, J. H. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.03.043 · Cited by 58 · see citing works
Social cognition in major depressive disorder: A new paradigm?
Billeke, P. B., Boardman, S., & Doraiswamy, P. M. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0147-9 · Cited by 52 · see citing works
Prefrontal, parietal, and limbic condition-dependent differences in bipolar disorder: a large-scale meta-analysis of functional neuroimaging studies
Schumer, M. C., Chase, H., Rozovsky, R., Eickhoff, S., & Phillips, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01974-8 · Cited by 47 · see citing works
“Nevertheless, we hope the ﬁ ndings of this meta-analysis show promise for the ability of functional neuroimaging to identify group-level differences distinguishing BD that can be leveraged to advance therapeutics in the coming years.”
Background
Altered directed functional connectivity of the right amygdala in depression: high-density EEG study
Damborská, A., Honzírková, E., Barteček, R., Hořínková, J., Fedorová, S., Ondruš, Š., Michel, C. M., & Rubega, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61264-z · Cited by 45 · see citing works
Aberrant functional connectivity of cortico-basal ganglia circuits in major depression
Marchand, W. R., Lee, J. N., Suchy, Y., Johnson, S., Thatcher, J. W., & Gale, P. D. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.063 · Cited by 44 · see citing works
Self-citation
Size and shape of the caudate nucleus in individuals with bipolar affective disorder
Ong, D., Walterfang, M., Malhi, G. S., Styner, M. A., Velakoulis, D., & Pantelis, C. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412440191 · Cited by 43 · see citing works
“…that bipolar disorder is generally associated with striatal overactivity at a functional level, whereas structural findings have been mixed and that the most likely reason for this variability is the use of antipsychotic medication, which affect striatal volume (Marchand and Yurgelun-Todd, 2010).”
BackgroundInfluential
Preventive effects of blueberry extract on behavioral and biochemical dysfunctions in rats submitted to a model of manic behavior induced by ketamine
Debom, G. N., Gazal, M., Soares, M. S. P., do Couto, C. A. T., de Mattos, B. D. S., Lencina, C. L., Kaster, M. P., Ghisleni, G., Tavares, R. G., Braganhol, E., et al. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.008 · Cited by 43 · see citing works
Sensorimotor Modulation of Mood and Depression: In Search of an Optimal Mode of Stimulation
Canbeyli, R. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00428 · Cited by 42 · see citing works
“…serves as the substrate for psychomotor symptoms of depression, but can also affect the circuitry that is responsible for mood by means of its direct and indirect bidirectional connectivity with the frontal cortices and the amygdala (Marchand and Yurgelun-Todd, 2010, 2012; Marchand et al., 2012).”
Background
Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus
Hagan, C. C., Graham, J. M., Tait, R. J., Widmer, B., van Nieuwenhuizen, A. O., Ooi, C., Whitaker, K. J., Simas, T., Bullmore, E. T., Lennox, B., et al. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.12.019 · Cited by 42 · see citing works
“…reward system, cortico-basal ganglia circuit, orbital prefrontal and medial prefrontal (which incorporates the fronto-limbic system) networks (Wilkinson and Goodyer, 2011; Graham et al., 2013; Roiser et al., 2012; Gotlib et al., 2010; Marchand and Yurgelun-Todd, 2010; Price and Drevets, 2012).”
Background
Deep brain stimulation for bipolar disorder—review and outlook
Gippert, S. M., Switala, C., Bewernick, B. H., Kayser, S., Bräuer, A., Coenen, V. A., & Schlaepfer, T. E. (2016) · CNS Spectrums · doi:10.1017/s1092852915000577 · Cited by 38 · see citing works
“Nevertheless, recent data point to the neurobiology of bipolar depression being very similar to unipolar major depression, mainly regarding striatal dysfunction.(19,20) Furthermore, anhedonia and lack of motivation are also prominent in bipolar patients who suffer from treatmentresistant depression.”
Background
Peripheral inflammation is associated with dysfunctional corticostriatal circuitry and executive dysfunction in bipolar disorder patients
Tseng, H., Chang, H. H., Wei, S., Lu, T., Hsieh, Y.-T., Yang, Y. K., & Chen, P. S. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.010 · Cited by 39 · see citing works
Striatal and cortical midline activation and connectivity associated with suicidal ideation and depression in bipolar II disorder
Marchand, W. R., Lee, J. N., Garn, C. L., Thatcher, J. W., Gale, P. D., Kreitschitz, S., Johnson, S., & Wood, N. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.04.039 · Cited by 38 · see citing works
Self-citation
Neuropathological substrates and structural changes in late-life depression: the impact of vascular burden
Xekardaki, A., Santos, M., Hof, P. R., Kövari, E., Bouras, C., & Giannakopoulos, P. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1021-5 · Cited by 36 · see citing works
“Mood disorders in late life are seen as the final byproduct of complex interactions between genetic predispositions, environmental influences, and neurobiological abnormalities [7, 14, 16, 88, 97].”
Background
Investigation of manic and euthymic episodes identifies state- and trait-specific gene expression and STAB1 as a new candidate gene for bipolar disorder
Witt, S. H., Juraeva, D., Sticht, C., Strohmaier, J., Meier, S. M., Treutlein, J., Dukal, H., Frank, J., Lang, M., Deuschle, M., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.71 · Cited by 34 · see citing works
Individuals with more severe depression fail to sustain nucleus accumbens activity to preferred music over time
Jenkins, L. M., Skerrett, K. A., DelDonno, S. R., Patrón, V. G., Meyers, K. K., Peltier, S., Zubieta, J., Langenecker, S. A., & Starkman, M. N. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.03.002 · Cited by 32 · see citing works
Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS
Macfarlane, M. D., Looi, J. C., Walterfang, M., Spulber, G., Velakoulis, D., Crisby, M., Örndahl, E., Erkinjuntti, T., Garde, E., Waldemar, G., et al. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.05.010 · Cited by 31 · see citing works
“The neostriatum, comprising the caudate nuclei and putamina, connects to a number of different cortical and subcortical structures (Marchland and Yurgelun-Todd, 2010).”
Background
Neuroretinal Alterations in Schizophrenia and Bipolar Disorder: An Updated Meta-analysis
Sheehan, N., Bannai, D., Silverstein, S. M., & Lizano, P. L. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae102 · Cited by 28 · see citing works
Relationship between frontostriatal morphology and executive function deficits in bipolar I disorder following a first manic episode: data from the Systematic Treatment Optimization Program for Early Mania (STOP‐EM)
Kozicky, J., Ha, T., Torres, I., Bond, D. J., Honer, W., Lam, R. W., & Yatham, L. N. (2013) · Bipolar Disorders · doi:10.1111/bdi.12103 · Cited by 32 · see citing works
Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study
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“The basal ganglia have close associations with sensorimotor, associative/cognitive, and limbic systems, and alterations in this region could be associated with BP patients [1, 36, 46, 50, 54, 98].”
Background
Self-Referential Thinking, Suicide, and Function of the Cortical Midline Structures and Striatum in Mood Disorders: Possible Implications for Treatment Studies of Mindfulness-Based Interventions for Bipolar Depression
Marchand, W. R. (2011) · Depression Research and Treatment · doi:10.1155/2012/246725 · Cited by 25 · see citing works
“A large literature documents the role of striatal and associated corticobasal ganglia circuitry dysfunction in affective disorders, see [166, 167] for recent reviews.”
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Elevated striatal γ-aminobutyric acid in youth with major depressive disorder
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“The striatum has been shown to be inextricably linked to reward function and is known to play a role in the pathophysiology of mood disorders (Marchand and Yurgelun-Todd, 2010).”
Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder
Wei, S., Tseng, H., Chang, H. H., Lu, T., Chang, W. H., Chiu, N.-T., Yang, Y. K., & Chen, P. S. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00972-6 · Cited by 24 · see citing works
Altered structural covariance of the striatum in functional dyspepsia patients
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Visuospatial planning in unmedicated major depressive disorder and bipolar disorder: distinct and common neural correlates
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“…striatal activity (Blumberg et al. 2000; Marchand & Yurgelun-Todd, 2010; Delvecchio et al. 2012; Hajek et al. 2013); whereas in remitted BD, both increased (Wessa et al. 2007; Marchand & Yurgelun-Todd, 2010) and decreased (Marchand & Yurgelun-Todd, 2010; Hajek et al. 2013) activity was reported.”
BackgroundInfluential
Robust presynaptic serotonin 5-HT1Breceptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment
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Effect of high-definition transcranial direct current stimulation on improving depression and modulating functional activity in emotion-related cortical-subcortical regions in bipolar depression
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Psychotic Symptom, Mood, and Cognition-associated Multimodal MRI Reveal Shared Links to the Salience Network Within the Psychosis Spectrum Disorders
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The Purinergic System as a Target for the Development of Treatments for Bipolar Disorder
Gonçalves, M. C. B., Andrejew, R., & Gubert, C. (2022) · CNS Drugs · doi:10.1007/s40263-022-00934-0 · Cited by 19 · see citing works
“The capability of adenosine receptors to form heterodimers with dopamine receptors becomes especially relevant in this context, as A2AR-D2R heterodimers in the basal ganglia regulate corticostriatal dopamine neurotransmission, found hyperactive in patients with BD [137, 138] (Fig.”
Background
CaMKK2 as an emerging treatment target for bipolar disorder
Kaiser, J., Nay, K., Horne, C. R., McAloon, L. M., Fuller, O. K., Muller, A. G., Whyte, D. G., Means, A. R., Walder, K. R., Berk, M., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02260-3 · Cited by 18 · see citing works
“In addition, lithium increases CaMKK2 expression in the striatum, an area of the brain that displays structural abnormalities in bipolar disorder [173, 174].”
Background
Comparison of shape alterations of the thalamus and caudate nucleus between drug-naïve major depressive disorder patients and healthy controls
Choi, K. W., Han, K., Kim, H., Kim, A., Kang, W., Kang, Y., Tae, W., & Ham, B. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.011 · Cited by 17 · see citing works
Striatal hypoactivation and cognitive slowing in patients with partially remitted and remitted major depression
Hammar, Å., Neto, E., Clemo, L., Hjetland, G. J., Hugdahl, K., & Elliott, R. (2016) · PsyCh Journal · doi:10.1002/pchj.134 · Cited by 18 · see citing works
“…linked to MDD in several studies and meta-analyses (Arnone, McIntosh, Ebmeier, Munafo, & Anderson, 2012; Emre Bora, Harrison, Davey, Yücel, & Pantelis, 2012; Kim, Hamilton, & Gotlib, 2008; Koolschijn et al., 2009; Macfarlane et al., 2013; Marchand & YurgelunTodd, 2010; Pizzagalli et al., 2009).”
Trait positive affect is associated with hippocampal volume and change in caudate volume across adolescence
Dennison, M., Whittle, S., Yücel, M., Byrne, M. L., Schwartz, O., Simmons, J. G., & Allen, N. B. (2014) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-014-0319-2 · Cited by 15 · see citing works
Shape and Volumetric Differences in the Corpus Callosum between Patients with Major Depressive Disorder and Healthy Controls
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Pallidal volume reduction and prefrontal-striatal-thalamic functional connectivity disruption in pediatric bipolar disorders
Zhang, X., Gao, W., Cao, W., Kuang, L., Niu, J., Guo, Y., Cui, D., Jiao, Q., Qiu, J., Su, L., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.01.049 · Cited by 14 · see citing works
Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder
Bootsman, F., Brouwer, R. M., Kemner, S. M., Schnack, H. G., van der Schot, A. C., Vonk, R., Hillegers, M. H. J., Boomsma, D. I., Pol, H. E. H., Nolen, W. A., et al. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.023 · Cited by 13 · see citing works
“In BD, particular attention has been given to abnormalities in subcortical brain regions that are part of or associated with the cortico-striatothalamic and limbic networks involved in emotion processing, including the amygdala, hippocampus, striatum and thalamus (Phillips et al., 2003, 2008; Emsell and McDonald, 2009…”
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Biological effects of inhaled crude oil vapor V. Altered biogenic amine neurotransmitters and neural protein expression
Sriram, K., Lin, G. X., Jefferson, A. M., McKinney, W., Jackson, M. C., Cumpston, J. L., Cumpston, J. B., Leonard, H. D., Kashon, M. L., & Fedan, J. S. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116137 · Cited by 12 · see citing works
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Monferrer, M., Ricarte, J. J., Montes, M. J., Fernández‐Caballero, A., & Fernández-Sotos, P. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.04.052 · Cited by 10 · see citing works
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Machine learning algorithm performance evaluation in structural magnetic resonance imaging-based classification of pediatric bipolar disorders type I patients
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“Additionally, functional neuroimaging ﬁndings have also demonstrated greater pallidual activity during a motor task in bipolar mania patients (Marchand and Yurgelun-Todd, 2010), and higher BOLD responses of left pallidum in BD mania groups (Caligiuri et al., 2003).”
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The neural correlates of perceived energy levels in older adults with late-life depression
Lam, C. L. M., Liu, H., Huang, C., Wai, Y., Lee, S., Yiend, J., Lin, C., & Lee, T. M. C. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9940-y · Cited by 8 · see citing works
Basal ganglia volumetric changes in psychotic spectrum disorders
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Mania during antidepressant withdrawal in late‐onset depression
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“This observation is consistent with earlier reports (Blumberg et al., 2003; Marchand and Yurgelun-Todd, 2010).”
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Attenuated inhibition of medium spiny neurons participates in the pathogenesis of childhood depression
Li, S., Liu, D., Hu, L., Zhang, J., & Zhang, P. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.133171 · Cited by 7 · see citing works
“Imaging studies have shown that DRD2 density is increased in the basal ganglia of depressive patients (D’Haenen H and Bossuyt, 1994; Marchand and Yurgelun-Todd, 2010).”
Background
Altered dynamic brain activity of recent suicidal ideation and suicidal attempt in depression patients and its relationship with cognitive function
Shen, N., Chen, Z., Sun, H. X., Tian, S., Wang, Y., Huang, Y., Yan, R., Hua, L., Yao, Z., & Lü, Q. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.054 · Cited by 7 · see citing works
To BD or not to BD: functional neuroimaging and the boundaries of bipolarity
Kuiper, S., McLean, L., & Malhi, G. S. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.126 · Cited by 6 · see citing works
Adenosinergic-Dopaminergic Signaling in Mood Disorders: A Mini-Review
Gonçalves, M. C. B., Glaser, T., de Oliveira, S. L. B., & Ulrich, H. (2020) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2020.0009 · Cited by 5 · see citing works
“91,92 Other works, however, found an association between the A1 allele of the polymorphism Taq1A on the DRD2 gene 93,94 and the allele 5 and genotype 5–5 of the intron 2 DRD2 microsatellite and the susceptibility to type II BPD. 95 The GG genotype of the Taq1A polymorphism has also been linked to the early onset of BP…”
The Serotonergic System and Its Role in Thermoregulation
Negoita, A., Amuzescu, B. P., Mihailescu, D. F., & Bordea, C. (2025) · Physiologia · doi:10.3390/physiologia5040037 · Cited by 4 · see citing works
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Hirnstimulationsverfahren
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“26 Moreover, striatal functional connectivity patterns also correlate with distinct mood symptoms.”
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“Nonetheless, current data point to the fact that the neurobiological aspects of bipolar depression are very similar to those of unipolar major depression, especially regarding striatal dysfunction (Marchand and Yurgelun-Todd 2010; Kupferschmidt and Zakzanis 2011).”
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Dhawan, V., Narayanan, S., Thompson, C. H., Shi, D., Patel, Y., McClung, C. A., & Cui, X. T. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124369 · Cited by 1 · see citing works
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“Functional abnormalities of the striatum and greater corticostriatal circuitry also exist in certain mood disorder subtypes, with evidence of striatal hypoactivity in unipolar depression (Marchand and Yurgelun-Todd, 2010), and reduced caudate nucleus volume in older people with depression (Hickie et al.”
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Striatal Functional Alterations Link to Distinct Symptomatology Across Mood States in Bipolar Disorder
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STRIATAL FUNCTIONAL CONNECTIVITY PATTERN ASSOCIATED WITH EMOTIONAL SYMPTOMS AND COGNITIVE PERFORMANCE IN MANIC/HYPOMANIC, EUTHYMIC AND DEPRESSIVE STATES OF BIPOLAR DISORDER
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Mood disorders – review of structural MRI studies
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Authors: Marchand, W. R., & Yurgelun‐Todd, D.
Affiliations: United States Department of Veterans Affairs (US)
Corresponding author: Marchand, William R
ORCID: Marchand, William R
Venue: Bipolar Disorders
Publisher: Wiley
Published: 2010-12
Volume: 12
Issue: 8
Pages: 764-785
ISSN: 1398-5647 (ISSN-L)
1399-5618
DOI: 10.1111/j.1399-5618.2010.00874.x
OpenAlex: W1608229171
Cited by: 91
References: 322
Citations by year: 2026: 4 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 15
FWCI: 1.35
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 21 d)
Locations: Bipolar Disorders (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: striatum, mood disorders, bipolar disorder, major depressive disorder, corticostriatal circuits, functional imaging
MeSH terms: Bipolar Disorder, Cerebral Cortex, Corpus Striatum, Humans, Magnetic Resonance Imaging, Mood Disorders

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Striatal structure and function in mood disorders: a comprehensive review

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