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Polylactic Acid for Surgical Implants
Abstract
LACTIC acid in its racemic or optically active form can undergo acid catalyzed homopolymerization to yield a polymer of lower molecular weight, which is not suitable for plastic or fibers.1However, the cyclic diester, the lactide2of lactic acid, can polymerize by anionic ring opening addition mechanism under the influence of catalysts to a high polymer, which can be cast into strong films or spun into fibers3-6comparable to the industrial polyesters like dacron. This property, and in addition, the possibility of this polyester undergoing hydrolytic de-esterification finally to the lactic acid, which is a normal intermediate in the lactic acid cycle of the carbohydrate metabolism, make this a highly interesting product as a synthetic surgical repair material possibly for vascular grafts and sutures. Moreover, the material is expected to elicit no immunological response due to the absence of peptide linkages. No literature references, however, are available
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Cited by
The return of a forgotten polymer—Polycaprolactone in the 21st century
Woodruff, M. A., & Hutmacher, D. W. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.04.002 · Cited by 4,033
Poly(lactic acid) modifications
Rasal, R. M., Janorkar, A. V., & Hirt, D. E. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.12.003 · Cited by 2,204
Biodegradable synthetic polymers for tissue engineering
CSIRO Molecular Science, B. 1., & Gunatillake, P. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a01 · Cited by 1,765
Athanasiou, K. A., Niederauer, G. G., & Agrawal, C. M. (1996) · Biomaterials · doi:10.1016/0142-9612(96)85754-1 · Cited by 1,497
Properties of lactic acid based polymers and their correlation with composition
Södergård, A., & Stolt, M. (2002) · Progress in Polymer Science · doi:10.1016/s0079-6700(02)00012-6 · Cited by 1,461
Metadata
- Authors
- KULKARNI, R. K.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1966-11-01
- Volume
- 93
- Issue
- 5
- Pages
- 839
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2077042278
- Cited by
- 841
- References
- 0
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
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