The return of a forgotten polymer—Polycaprolactone in the 21st century

Woodruff, Maria Ann; Hutmacher, Dietmar Werner

doi:10.1016/j.progpolymsci.2010.04.002

Cited by 4,033biodegradable polymer synthesis and propertiesSurgical Sutures and AdhesivesAdvanced Drug Delivery Systems

The return of a forgotten polymer—Polycaprolactone in the 21st century

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Woodruff, Maria Ann, Hutmacher, Dietmar Werner·2010·Progress in Polymer Science

DOI 10.1016/j.progpolymsci.2010.04.002

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PCL is semi-crystalline with a reported degree of crystallinity of ca. 40%, a melting temperature of 58-64 °C, and a glass transition temperature of −65 to −60 °C.
“PCL is semi-crystalline, with spherulites consisting of lamellae oriented in parallel and separated by amorphous regions with a reported degree of crystallinity of ca. 40%, a melting temperature in the range of 58–64 °C, and a glass transition temperature in the range of −65 to −60 °C (see Table 1) [35,46,47]”
From Nanocellulose-Reinforced Poly(Lactic Acid) and Poly(ε-caprolactone) Bio-Nanocomposites: A Review and Future Outlook for Poly(Lactic Acid)/Poly(ε-caprolactone) Blend Systems (2025) · cites this paper as [35]
Section 2 (page unavailable) describes PCL as semi-crystalline, with a glass transition temperature of −60 °C and a melting range of 59–64 °C. The cited copy does not give approximately 40% crystallinity or the claimed lower bounds of −65 °C and 58 °C. (LLM, conf=0.88)
Experimental — accuracy not yet measured
The required time for complete resorption of PDLLA is approximately 1-2 years, whilst PCL requires 2-4 years.
“It was reported that the required time for complete resorption (degradation time) of poly(D,L-lactide) (PDLLA) is approximately 1-2 years, whilst poly(ɛ-caprolactone) (PCL) requires 2-4 years [1,67,68].”
From In vitro degradation and mechanical properties of PLA-PCL copolymer unit cell scaffolds generated by two-photon polymerization (2016) · cites this paper as [1]
Section 3 (Biodegradation; page not provided) states that PCL homopolymer takes two to four years to degrade completely, depending on its starting molecular weight. The copy does not give a one-to-two-year complete-resorption time for PDLLA; Section 1 says only that PCL degrades more slowly than poly(D,L-lactide). (LLM, conf=0.88)
Experimental — accuracy not yet measured
PLA tensile strengths are in the range of 50-70 MPa.
“Woodruff et al. [35] reported tensile strengths in the range of 50–70 MPa.”
From Nanocellulose-Reinforced Poly(Lactic Acid) and Poly(ε-caprolactone) Bio-Nanocomposites: A Review and Future Outlook for Poly(Lactic Acid)/Poly(ε-caprolactone) Blend Systems (2025) · cites this paper as [35]
Section 8.6 discusses the mechanical behavior of PLA-containing scaffolds, but does not give a tensile-strength range for PLA. Searches for “50–70 MPa” and PLA tensile strength found no passage in our copy reporting the claimed range; no page number was available for the passages reviewed. (LLM, conf=0.73)
Experimental — accuracy not yet measured

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Background
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Authors: Woodruff, M. A., & Hutmacher, D. W.
Affiliations: Queensland University of Technology (AU)
Corresponding author: Hutmacher, Dietmar Werner
ORCID: Woodruff, Maria Ann
Hutmacher, Dietmar Werner
Venue: Progress in Polymer Science
Publisher: Elsevier BV
Published: 2010-10
Volume: 35
Issue: 10
Pages: 1217-1256
ISSN: 0079-6700 (ISSN-L)
DOI: 10.1016/j.progpolymsci.2010.04.002
OpenAlex: W1509303906
Cited by: 4,033
References: 194
Citations by year: 2026: 257 · 2025: 293 · 2024: 256 · 2023: 250 · 2022: 312 · 2021: 327 · 2020: 331 · 2019: 319 · 2018: 324 · 2017: 279 · 2016: 271 · 2015: 245 · 2014: 197 · 2013: 160 · 2012: 125
FWCI: 48.35
Type: journal article
Language: en
Open access: green
eprints.qut.edu.au
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Polymer Science (publishedVersion)
QUT ePrints (Queensland University of Technology) (submittedVersion)
Faculty of Built Environment and Engineering; Institute of Health and Biomedical Innovation
Institute of Health and Biomedical Innovation
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: polycaprolactone, resorbable polymers, biodegradable implants, drug delivery, tissue engineering, degradation kinetics, rheological properties, viscoelasticity, aliphatic polyesters, medical devices, biomaterials

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