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Multiple System Organ Failure: The Role of Uncontrolled Infection
Abstract
Multiple system organ failure (MSOF) remains a principal cause of death after major operative procedures and/or severe trauma. We studied multiple parameters in 553 consecutive emergency surgical patients to determine the incidence of MSOF, the predisposing factors to MSOF, and the sequelae of MSOF. Thirty-eight patients had MSOF; mortality was 74% for these patients. Evaluation of multiple factors demonstrated that (1) MSOF is primarily due to infection, (2) the temporal sequence of organ failure is lung, liver, gastric mucosa, and kidney, and (3) MSOF is the most common fatal expression of uncontrolled infection.
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Cited by
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Postinjury Multiple Organ Failure: A Bimodal Phenomenon
Moore, F. A., Sauaia, A., Moore, E. E., Haenel, J. B., Burch, J. M., & Lezotte, D. C. (1996) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199604000-00001 · Cited by 491
Marshall, J. C. (1988) · Archives of Surgery · doi:10.1001/archsurg.1988.01400270043006 · Cited by 328
Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems
Seely, A. J. E., & Christou, N. V. (2000) · Critical Care Medicine · doi:10.1097/00003246-200007000-00003 · Cited by 287
Metadata
- Authors
- Fry, D. E.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1980-02-01
- Volume
- 115
- Issue
- 2
- Pages
- 136
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W1979109569
- Cited by
- 735
- References
- 0
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
