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Pancreatic Cancer: Adjuvant Combined Radiation and Chemotherapy Following Curative Resection
Abstract
The efficacy of combined radiation and fluorouracil as adjuvant therapy for pancreatic cancer is suggested by a prospective randomized study conducted by the Gastrointestinal Tumor Study Group (GITSG). Twenty-two patients randomized to no adjuvant treatment and 21 to combined therapy were analyzed. Neither life-threatening toxic reaction nor death due to toxic effect was encountered. The study was terminated prematurely because of an unacceptably low rate of accrual combined with the observation of increasingly large survival differences between the study arms. Median survival for the treatment group (20 months) was significantly longer than that observed for the control group (11 months). Four patients, three in the treated and one in the control group, have survived five years or longer following surgery. The extent of the tumor and initial performance status were significantly and independently related to survival.
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Cited by
A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer
Neoptolemos, J. P., Stocken, D. D., Friess, H., Bassi, C., Dunn, J. A., Hickey, H., Beger, H., Fernandez-Cruz, L., Dervenis, C., Lacaine, F., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032295 · Cited by 2,716
Royal, R. E., Levy, C., Turner, K., Mathur, A., Hughes, M., Kammula, U. S., Sherry, R. M., Topalian, S. L., Yang, J. C., Lowy, I., et al. (2010) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181eec14c · Cited by 1,257
Therapeutic developments in pancreatic cancer: current and future perspectives
Neoptolemos, J. P., Kleeff, J., Michl, P., Costello, E., Greenhalf, W., & Palmer, D. H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0005-x · Cited by 1,170
Optimizing the outcomes of pancreatic cancer surgery
Strobel, O., Neoptolemos, J., Jäger, D., & Büchler, M. W. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0112-1 · Cited by 943
Cancer of the pancreas: 50 years of surgery
Gudjonsson, B. (1987) · Cancer · doi:10.1002/1097-0142(19871101)60:9<2284::aid-cncr2820600930>3.0.co;2-v · Cited by 616
Metadata
- Authors
- Kaiser, M. H.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1985-08-01
- Volume
- 120
- Issue
- 8
- Pages
- 899
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2150881991
- Cited by
- 1,406
- References
- 0
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kaiser, M. H. (1985). Pancreatic Cancer: Adjuvant Combined Radiation and Chemotherapy Following Curative Resection. Archives of Surgery. https://doi.org/10.1001/archsurg.1985.01390320023003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
