Therapeutic developments in pancreatic cancer: current and future perspectives
Abstract
The overall 5-year survival for pancreatic cancer has changed little over the past few decades, and pancreatic cancer is predicted to be the second leading cause of cancer-related mortality in the next decade in Western countries. The past few years, however, have seen improvements in first-line and second-line palliative therapies and considerable progress in increasing survival with adjuvant treatment. The use of biomarkers to help define treatment and the potential of neoadjuvant therapies also offer opportunities to improve outcomes. This Review brings together information on achievements to date, what is working currently and where successes are likely to be achieved in the future. Furthermore, we address the questions of how we should approach the development of pancreatic cancer treatments, including those for patients with metastatic, locally advanced and borderline resectable pancreatic cancer, as well as for patients with resected tumours. In addition to embracing newer strategies comprising genomics, stromal therapies and immunotherapies, conventional approaches using chemotherapy and radiotherapy still offer considerable prospects for greater traction and synergy with evolving concepts.
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Median survival on various chemotherapies for pancreatic cancer is poor and often does not exceed 12-18 months.
“Median survival on various chemotherapies is poor and often does not exceed 12–18 months (3).”
From KRAS mutation in pancreatic cancer (2021) · cites this paper as [3]
Survival rates are substantially better for patients diagnosed at an operable rather than an inoperable stage of pancreatic ductal adenocarcinoma.
“Survival rates are also substantially better for patients diagnosed at an operable rather than an inoperable stage.9”
From Early detection of pancreatic cancer (2020) · cites this paper as [9]
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- Authors
- Neoptolemos, J. P., Kleeff, J., Michl, P., Costello, E., Greenhalf, W., & Palmer, D. H.
- Affiliations
- Heidelberg University (DE)
- Martin Luther University Halle-Wittenberg (DE)
- University of Liverpool (GB)
- Corresponding author
- Neoptolemos, John P.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2018-05-01
- Volume
- 15
- Issue
- 6
- Pages
- 333-348
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W2800389517
- Cited by
- 1,170
- References
- 13
- Citations by year
- 2026: 54 · 2025: 142 · 2024: 141 · 2023: 201 · 2022: 183 · 2021: 217 · 2020: 144 · 2019: 71 · 2018: 17
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pancreatic Cancer UK (RIF2014_03_Costello)
- European Cooperation in Science and Technology
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Keywords
- pancreatic cancer, adjuvant therapy, neoadjuvant therapy, biomarkers, chemotherapy, radiotherapy, immunotherapy, metastatic pancreatic cancer, locally advanced pancreatic cancer, borderline resectable pancreatic cancer, resected pancreatic cancer, genomics, cancer survival
- MeSH terms
- Antineoplastic Agents, Combined Modality Therapy, Forecasting, Humans, Immunotherapy, Palliative Care, Pancreatic Neoplasms, Biomedical Research, Precision Medicine
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