The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Effects of Cardiopulmonary Bypass on Pulmonary Leukostasis and Complement Activation
Abstract
We measured white blood cell counts and complement component (C3a, C4a, and C5a) and prostacyclin levels, and studied lung biopsy specimens, in 16 patients undergoing cardiopulmonary bypass and compared them with four patients undergoing other pulmonary procedures. Bypass caused no significant elevation in peripheral venous white blood cell counts. Higher counts were present in the right atrium compared with the left atrium. Patients who underwent bypass had elevated complement component and prostacyclin concentrations before operation and these levels increased further during operation. Trapping of polymorphonuclear leukocytes occurred in pulmonary alveolar capillaries and venules after bypass. We conclude that bypass activates complement components primarily of the alternative pathway and leads to increased blood prostacyclin levels. These changes are accompanied by polymorphonuclear leukocyte accumulation in the lungs and may be important in initiation of the adult respiratory distress syndrome in these patients.
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Cardiopulmonary bypass (CPB) is an immuno-reactive state in which neutrophils are activated and accumulate in different tissues.
“Cardiopulmonary bypass (CPB) is an immuno-reactive state where neutrophils are activated and accumulate in different tissues.”
From Oral neutrophils are an independent marker of the systemic inflammatory response after cardiac bypass (2014) · cites this paper as [6]
Citations
Cites
Complement and the damaging effects of cardiopulmonary bypass
Kirklin, J. K., Westaby, S., Blackstone, E. H., Kirklin, J. W., Chenoweth, D. E., & Pacifico, A. D. (1983) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)39061-0 · Cited by 1,322
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Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis
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Complement activation during cardiopulmonary bypass
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Complement activation and pulmonary leukotasis during nylon fiber filtration leukapheresis
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Complement activation during major operations with or without cardiopulmonary bypass
Fosse, E. T., Molines, T. E., & Ingvaldsen, B. (1987) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)37046-1 · Cited by 114
Changes in serum complement and immunoglobulins following cardiopulmonary bypass.
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Faymonville, M.-É., Deby-Dupont, G. P., Larbuisson, R., et al. (1986) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)35964-1 · Cited by 103
The effect of body temperature on leukocyte kinetics during cardiopulmonary bypass
Quiroga, M. M., Miyagishima, R. T., Haendschen, L. C., et al. (1985) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(19)38668-4 · Cited by 67
Pulmonary lesions produced by prolonged perfusion.
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Anaphylatoxin Formation in Extracorporeal Circuits
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Prostacyclin release following endoperoxide analogue infusion in the intact dog
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Effect of cardiopulmonary bypass on plasma fibronectin, IgG, and C3
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PROSTACYCLIN AND EXTRACORPOREAL CIRCULATION
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Wilcox, M. E., Charbonney, E., d’Empaire, P. P., Duggal, A., Pinto, R., Javid, A., Dos Santos, C., Rubenfeld, G. D., Sutherland, S., Liles, W. C., et al. (2014) · Journal of Inflammation · doi:10.1186/s12950-014-0032-5 · Cited by 17
“the bypass circuit, mechanical shear stress and hemodilution, [3-6] and as a result accumulate in different tissues.”
Background
Metadata
- Authors
- Howard, R. J.
- Affiliations
- University of Florida (US)
- Corresponding author
- Howard, Richard J.
- ORCID
- Howard, Richard J.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1988-12-01
- Volume
- 123
- Issue
- 12
- Pages
- 1496
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2073755681
- Cited by
- 104
- References
- 20
- Citations by year
- 2024: 2 · 2020: 1 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL16411, HL-25658)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- cardiopulmonary bypass, pulmonary leukostasis, complement activation, alternative complement pathway, prostacyclin, polymorphonuclear leukocytes, acute respiratory distress syndrome, C3a, C4A, C5a
- MeSH terms
- Adult, Aged, Arteriosclerosis, Cardiopulmonary Bypass, Complement Activation, Complement Pathway, Alternative, Complement C3, Complement C4, Complement C5, Female, Humans, Leukocyte Count, Leukocytosis, Lung, Male, Middle Aged, Neutrophils, Platelet Count, Time Factors, 6-Ketoprostaglandin F1 alpha
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