The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Intra-arterial Floxuridine vs Systemic Fluorouracil for Hepatic Metastases From Colorectal Cancer: A Randomized Trial
Abstract
Seventy-four patients with liver metastasis from proved colorectal primary adenocarcinoma were entered into a prospective, randomized clinical trial to evaluate treatment with intra-arterial floxuridine compared with standard outpatient therapy with fluorouracil delivered by intravenous bolus injection. Eligible patients were randomized to hepatic arterial chemotherapy with an implanted infusion pump or systemic chemotherapy. No crossover between treatment arms was permitted, and patients were followed up to progression and death. Objective tumor response was observed in 48% of patients receiving intra-arterial floxuridine and in 21% of patients receiving intravenous fluorouracil. Time to hepatic progression was significantly longer in the group given intra-arterial therapy: 15.7 vs 6.0 months. However, time to overall progression (6.0 vs 5.0 months) and survival (12.6 vs 10.5 months) were not statistically different. Based on these data, we cannot recommend treatment with intra-arterial floxuridine as given in this study for metastatic colorectal cancer to the liver.
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Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,181
Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
(1959) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/22.4.719 · Cited by 14,689
The blood supply of neoplasms in the liver.
Breedis, C., & Young, G. P. (2003) · PubMed · Cited by 1,290
KEMENY, N., DALY, J., REICHMAN, B., GELLER, N., BOTET, J., & ODERMAN, P. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-459 · Cited by 649
Resection of Hepatic Metastases from Colorectal Cancer Biologic Perspectives
STEELE, G., & RAVIKUMAR, T. S. (1989) · Annals of Surgery · doi:10.1097/00000658-198908000-00001 · Cited by 525
Ensminger, W. D., Rosowsky, A., Raso, V., Levin, D. C., Glodé, M., Come, S. E., Steele, G. D., & Frei, E. (1978) · PubMed · Cited by 521
Cited by
Kemeny, N. E., Niedzwiecki, D., Hollis, D. R., Lenz, H.-J., Warren, R. S., Naughton, M. J., Weeks, J. C., Sigurdson, E. R., Herndon, J. E., Zhang, C., et al. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.8166 · Cited by 417
Metadata
- Authors
- Martin, J. K.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1990-08-01
- Volume
- 125
- Issue
- 8
- Pages
- 1022
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2122364701
- Cited by
- 375
- References
- 7
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Intra-arterial Floxuridine vs Systemic Fluorouracil for Hepatic Metastases From Colorectal Cancer: A Randomized Trial. https://app.cochat.ai/papers/10.1001/archsurg.1990.01410200086013
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- Martin, J. K. (1990). Intra-arterial Floxuridine vs Systemic Fluorouracil for Hepatic Metastases From Colorectal Cancer: A Randomized Trial. Archives of Surgery. https://doi.org/10.1001/archsurg.1990.01410200086013
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
