The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
Leukocyte Responses to Injury
Abstract
Injury elicits a response from all cells of the immune system in which cytokines and other metabolic products of activated leukocytes can act either beneficially to provide for enhanced host resistance or deleteriously to depress the function of remote organs and cause what has been termed systemic inflammation. These at times antithecal responses of leukocytes that appear to integrate postinjury changes in the neuroendocrine, immune, and coagulation systems have been implicated as principal causative factors in multiple systems organ failure. Numerous investigators have evaluated a variety of therapeutic agents to prevent and control infection by restoring leukocyte function, while others have evaluated antagonists and monoclonal antibodies as a means of controlling the exaggerated and persistent actions of leukocytes and cytokines caused by systemic inflammation. The redundancies of the cell populations and the cytokines and other metabolites produced by the cells predictably limit the effectiveness of any single agent and make clinical evaluation of such agents difficult.
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“Successful repair of injured tissues requires diverse interactions among different cells, biochemical mediators, and the cellular microenvironment47–49.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [48]
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Metadata
- Authors
- Cioffi, W. G.
- Affiliations
- United States Army Institute of Surgical Research (US)
- Corresponding author
- Cioffi, William G.
- ORCID
- Cioffi, William G.
- Venue
- Archives of Surgery
- Publisher
- American Medical Association (AMA)
- Published
- 1993-11-01
- Volume
- 128
- Issue
- 11
- Pages
- 1260
- ISSN
- 0004-0010 (ISSN-L)
- OpenAlex
- W2066356532
- Cited by
- 71
- References
- 76
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Defense Technical Information Center (DTIC) (submittedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- systemic inflammation, multiple organ failure, cytokines, leukocyte activation, neuroendocrine-immune interaction, coagulation, infection control, monoclonal antibodies, cytokine antagonists, host resistance
- MeSH terms
- Antibodies, Monoclonal, B-Lymphocytes, Blood Coagulation, Chemotaxis, Leukocyte, Complement Activation, Granulocytes, Humans, Immunity, Innate, Infections, Inflammation, Leukocytes, Multiple Organ Failure, Neurosecretory Systems, Oxidation-Reduction, T-Lymphocytes, Wounds and Injuries, Lymphocyte Subsets, Cytokines
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