Cited by 71Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysImmune Response and Inflammation

The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.

Leukocyte Responses to Injury

Cioffi, William G.·1993·Archives of Surgery

DOI 10.1001/archsurg.1993.01420230088014

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Abstract

Injury elicits a response from all cells of the immune system in which cytokines and other metabolic products of activated leukocytes can act either beneficially to provide for enhanced host resistance or deleteriously to depress the function of remote organs and cause what has been termed systemic inflammation. These at times antithecal responses of leukocytes that appear to integrate postinjury changes in the neuroendocrine, immune, and coagulation systems have been implicated as principal causative factors in multiple systems organ failure. Numerous investigators have evaluated a variety of therapeutic agents to prevent and control infection by restoring leukocyte function, while others have evaluated antagonists and monoclonal antibodies as a means of controlling the exaggerated and persistent actions of leukocytes and cytokines caused by systemic inflammation. The redundancies of the cell populations and the cytokines and other metabolites produced by the cells predictably limit the effectiveness of any single agent and make clinical evaluation of such agents difficult.

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PECAM-1 is required for transendothelial migration of leukocytes.
Müller, W. A., Weigl, S. A., Deng, X., & Phillips, D. M. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.449 · Cited by 1,151
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.
Nathan, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113241 · Cited by 791
Signal transduction and cytoskeletal activation in the neutrophil.
Omann, G. M., Allen, R. A., Bokoch, G., Painter, R. G., Traynor, A. E., & Sklar, L. A. (1987) · Physiological Reviews · doi:10.1152/physrev.1987.67.1.285 · Cited by 280
Establishing optimal lymphocyte gates for immunophenotyping by flow cytometry
Loken, M. R., Brosnan, J. M., Bach, B. A., & Ault, K. A. (1990) · Cytometry · doi:10.1002/cyto.990110402 · Cited by 263
C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp.
Wright, S. D., Reddy, P. A., Jong, M. T. C., & Erickson, B. W. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.7.1965 · Cited by 161
Enhancement of Neutrophil Function as a Result of Prior Exposure to Chemotactic Factor
Epps, D. E. V., & Garcia, M. L. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109841 · Cited by 159
Cortisol and Corticotrophin in Burned Patients
Vaughan, G. M., BECKER, R. A., Allen, J. P., Goodwin, C. W., Pruitt, B. A., & Mason, A. D. (1982) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198204000-00001 · Cited by 158
Inhibition of CD18-dependent neutrophil adherence reduces organ injury after hemorrhagic shock in primates.
Mileski, W. J., Winn, R. K., Vedder, N. B., Pohlman, T. H., Harlan, J. M., & Rice, C. L. (1990) · PubMed · Cited by 155
Neutrophil Activation in Thermal Injury as Assessed by Increased Expression of Complement Receptors
Moore, F. D., Davis, C. F., Rodrick, M. L., Mannick, J. A., & Fearon, D. T. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604103141503 · Cited by 148
Temporal correlation of impaired immune response after thermal injury with susceptibility to infection in a murine model.
Moss, N. M., Gough, D. B., Jordan, A., Grbic, J. T., Wood, J. J., Rodrick, M. L., & Mannick, J. A. (1988) · PubMed · Cited by 137
Endotoxemia in burn patients: levels of circulating endotoxins are related to burn size.
Winchurch, R. A., Thupari, J. N., & Munster, A. M. (1987) · PubMed · Cited by 128
Peripheral Blood Leukocyte Kinetics Following In Vivo Lipopolysaccharide (LPS) Administration to Normal Human Subjects
Richardson, R. P., Rhyne, C. D., Fong, Y., HESSE, D. G., Tracey, K. J., Marano, M. A., Lowry, S. F., Antonacci, A. C., & Calvano, S. E. (1989) · Annals of Surgery · doi:10.1097/00000658-198908000-00018 · Cited by 124
Neutrophil dysfunction and sepsis in burn injury.
Jw, A., & Wixson, D. (1970) · PubMed · Cited by 121
Evaluation of Leukocyte Chemotaxis In Vitro in Thermally Injured Patients
Warden, G. D., Mason, A. D., & Pruitt, B. A. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107815 · Cited by 120
The Role of Prostaglandin E2 in Immune Suppression Following Injury
Grbic, J. T., Mannick, J. A., Gough, D. B., & Rodrick, M. L. (1991) · Annals of Surgery · doi:10.1097/00000658-199109000-00008 · Cited by 111
Multiple Organ Failure
Anderson, B. O., & Harken, A. H. (1990) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199012001-00012 · Cited by 96
Inhibition of leukocyte-endothelial adherence following thermal injury
Mileski, W. J., Borgstrom, D., Lightfoot, E., Rothlein, R., Faanes, R. B., Lipsky, P. E., & Baxter, C. R. (1992) · Journal of Surgical Research · doi:10.1016/0022-4804(92)90112-d · Cited by 93
Immunofluorescent analysis of blood cells by flow cytometry
Hoffman, R. A., & Hansen, W. P. (1981) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(81)90018-7 · Cited by 77
Alternative complement pathway activation increases mortality in a model of burn injury in mice.
Gelfand, J. A., Donelan, M. B., Hawiger, A., & Burke, J. F. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110715 · Cited by 65
Immunomodulatory Therapy With Thymopentin and Indomethacin
Faist, E., Markewitz, A., Fuchs, D., Lang, S., ZARIUS, S., Schildberg, F.-W., WACHTER, H., & Reichart, B. (1991) · Annals of Surgery · doi:10.1097/00000658-199109000-00009 · Cited by 59
Chemotactic deactivation of human neutrophils: possible relationship to stimulation of oxidative metabolism
Nelson, R. D., Mccormack, R. T., Fiegel, V. D., Herron, M. J., Simmons, R. L., & Quie, P. G. (1979) · Infection and Immunity · doi:10.1128/iai.23.2.282-286.1979 · Cited by 58
HEAD INJURY
Hoyt, D. B., Özkan, A., Hansbrough, J. F., & Marshall, L. F. (1989) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198907000-00043 · Cited by 57
Increased PMN CD11b/CD18 expression following post-traumatic ARDS
Simms, H. H., & D'Amico, R. D. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90204-y · Cited by 57
Changes in Lymphocyte Number and Phenotype in Seven Lymphoid Compartments After Thermal Injury
ORGAN, B. C., ANTHONACCI, A. C., CHIAO, J., CHIAO, J., Kumar, A., de Riesthal, H. F., YUAN, L., BLACK, D., & Calvano, S. E. (1989) · Annals of Surgery · doi:10.1097/00000658-198907000-00012 · Cited by 52
Regulation of Neutrophil Migratory Function in Burn Injury by Complement Activation Products
Solomkin, J. S., Nelson, R. D., Chenoweth, D. E., Solem, L. D., & Simmons, R. L. (1984) · Annals of Surgery · doi:10.1097/00000658-198412000-00012 · Cited by 51
Cell-mediated immunity in severely head-injured patients: the role of suppressor lymphocytes and serum factors
Quattrocchi, K. B., Miller, C. H., Wagner, F. C., DeNardo, S. J., DeNardo, G. L., Ovodov, K., & FRANK, E. H. (1992) · Journal of neurosurgery · doi:10.3171/jns.1992.77.5.0694 · Cited by 47
Lymphoid Subpopulation Changes after Thermal Injury and Thermal Injury with Infection in an Experimental Model
Burleson, D. G., Mason, A. D., & Pruitt, B. A. (1988) · Annals of Surgery · doi:10.1097/00000658-198802000-00016 · Cited by 46
Specific changes in peripheral blood lymphocyte phenotype from burn patients. Probable origin of the thermal injury-related lymphocytopenia
y Aibar, M. D. M., Venturoli, A., Franco, A., & Nunez-Roldan, A. (1991) · Burns · doi:10.1016/0305-4179(91)90101-l · Cited by 45
Differential Regulation of T- and B-Lymphocyte Activation in Severely Burned Patients
Schlüter, B., König, W., Köller, M., ERBS, G., & Müller, F. E. (1991) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199102000-00015 · Cited by 44
Increase of serum interleukin 2 receptor level in thermally injured patients
Teodorczyk-Injeyan, J. A., Sparkes, B. G., Mills, G. B., Falk, R. E., & Peters, W. J. (1989) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(89)90020-2 · Cited by 43
Microtubule Assembly and Function in Normal and Glutathione Synthetase-Deficient Polymorphonuclear Leukocytes
Oliver, J. M., Spielberg, S. P., Pearson, C. B., & Schulman, J. D. (1978) · The Journal of Immunology · doi:10.4049/jimmunol.120.4.1181 · Cited by 43
The Role of Formylpeptide Receptors, C5a Receptors, and Cytosolic-Free Calcium in Neutrophil Priming
Zimmerli, W., Reber, A.-M., & Dahinden, C. A. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/161.2.242 · Cited by 42
A Randomized Trial of Replacement Antioxidant Vitamin Therapy for Neutrophil Locomotory Dysfunction in Blunt Trauma
Maderazo, E. G., Woronick, C. L., HICKINGBOTHAM, N., Jacobs, L. M., & BHAGAVAN, H. N. (1991) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199108000-00014 · Cited by 41
Transient inhibition of neutrophil adherence with the anti-CD18 monoclonal antibody 60.3 does not increase mortality rates in abdominal sepsis.
Mileski, W. J., Winn, R. K., Harlan, J. M., & Rice, C. L. (1991) · PubMed · Cited by 40
Immunosuppression follows systemic T lymphocyte activation in the burn patient
Teodorczyk-Injeyan, J. A., Sparkes, B. G., Mills, G. B., & Peters, W. J. (1991) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1991.tb05759.x · Cited by 38
Inappropriate Activation, Deactivation, and Probable Autooxidative Damage as a Mechanism of Neutrophil Locomotory Defect in Trauma
Maderazo, E. G., Woronick, C. L., Albano, S., Breaux, S. P., & Pock, R. M. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.3.471 · Cited by 38
Different Lymphocyte Compartments Respond Differently to Mitogenic Stimulation After Thermal Injury
Deitch, E. A., Xu, D.-Z., & Gi, L. (1990) · Annals of Surgery · doi:10.1097/00000658-199001000-00013 · Cited by 37
Resistance to Infection in Burned Patients
Balch, H. H., WATTERS, M., & Kelley, D. (1963) · Annals of Surgery · doi:10.1097/00000658-196301000-00001 · Cited by 37
Impaired Antibody Production in Blunt Trauma
McRitchie, D. (1990) · Archives of Surgery · doi:10.1001/archsurg.1990.01410130097013 · Cited by 36
Neutrophil-endothelial cell binding in neutrophil-mediated tissue injury
Ossa, J. C., Malagó, M., & Gewertz, B. L. (1992) · Journal of Surgical Research · doi:10.1016/0022-4804(92)90020-z · Cited by 36
Oxidative Activity of Polymorphonuclear Leukocytes After Thermal Injury
Dobke, M. K. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410070116023 · Cited by 35
Neutrophil activation after burn injury: contributions of the classic complement pathway and of endotoxin.
Cf, D., Moore, F. D., Rodrick, M. L., Fearon, D. T., & Mannick, J. A. (1987) · PubMed · Cited by 35
Expression and Secretion of IL-2 Receptor in Trauma Patients
Teodorczyk-Injeyan, J. A., McRitchie, D., Peters, W. J., Lalani, S., & Girotti, M. J. (1990) · Annals of Surgery · doi:10.1097/00000658-199008000-00015 · Cited by 31
Additional evidence of autoxidation as a possible mechanism of neutrophil locomotory dysfunction in blunt trauma
Maderazo, E. G., Woronick, C. L., HICKINGBOTHAM, N., MERCIER, E., Jacobs, L. M., & BHAGAVAN, H. N. (1990) · Critical Care Medicine · doi:10.1097/00003246-199002000-00003 · Cited by 30
Temporal analysis of human leucocyte surface antigen expression and neutrophil respiratory burst activity after thermal injury
Zapata-Sirvent, R. L., & Hansbrough, J. F. (1993) · Burns · doi:10.1016/0305-4179(93)90093-n · Cited by 30
Properdin and the defence of burns against infection
Lowbury, E. J. L., Ricketts, C. R., Hall, M., Hurst, L., & Lilly, H. A. (1957) · Journal of Hygiene · doi:10.1017/s0022172400037153 · Cited by 28
Comparison of numerical and phenotypic leukocyte changes during constant hydrocortisone infusion in normal humans with those in thermally injured patients.
Se, C., Jd, A., Legaspi, A., ORGAN, B. C., Tracey, K. J., Sf, L., Shires, G. T., & Antonacci, A. C. (1987) · PubMed · Cited by 28
Efficacy of Liver Wound Healing by Secondary Intent
Dulchavsky, S. A., LUCAS, C. E., Ledgerwood, A. M., Grabow, D., & An, T. (1990) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199001000-00007 · Cited by 27
Immunologic alterations in a murine model of hemorrhagic shock
Zapata-Sirvent, R. L., Hansbrough, J. F., COX, M. C., & Carter, W. H. (1992) · Critical Care Medicine · doi:10.1097/00003246-199204000-00013 · Cited by 27
Terminal B-Cell Maturation and Immunoglobulin (Ig) Synthesis in vitro in Patients with Major Injury
Faist, E., Ertel, W., Baker, C. C., & Heberer, G. (1989) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198901000-00002 · Cited by 24
Granulocyte oxidative activity after thermal injury.
Cioffi, W. G., Burleson, D. G., Jordan, B. S., Mason, A. D., & Pruitt, B. A. (1992) · PubMed · Cited by 23
Self-citation
Nonsteroidal Anti-Inflammatory Drugs Correct the Bactericidal Defect of Polymorphonuclear Leukocytes in a Guinea Pig Model of Thermal Injury
Bjornson, A. B., Knippenberg, R. W., & BJORNSON, H. S. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/157.5.959 · Cited by 23
Bactericidal defect of neutrophils in a guinea pig model of thermal injury is related to elevation of intracellular cyclic-3',5'-adenosine monophosphate.
Bjornson, A. B., Knippenberg, R. W., & BJORNSON, H. S. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.8.2609 · Cited by 20
Effect of Combined Cortisol-Endotoxin Administration on Peripheral Blood Leukocyte Counts and Phenotype in Cortisol-Endotoxin
Calvano, S. E. (1992) · Archives of Surgery · doi:10.1001/archsurg.1992.01420020067010 · Cited by 20
Flow Cytometric Measurement of Rat Lymphocyte Subpopulations After Burn Injury and Burn Injury With Infection
Burleson, D. G. (1987) · Archives of Surgery · doi:10.1001/archsurg.1987.01400140098013 · Cited by 20
Studies on B-lymphocyte Dysfunctions in Severely Burned Patients
Schlüter, B., König, W., Köller, M., ERBS, G., & Müller, F. E. (1990) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199011000-00011 · Cited by 18
Interleukin-2 Secretion and Transmembrane Signalling in Burned Patients
Teodorczyk-Injeyan, J. A., Sparkes, B. G., Falk, R. E., Peters, W. J., & MILLS, G. B. (1988) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198802000-00004 · Cited by 18
IL-2 regulation of soluble IL-2 receptor levels following thermal injury
Teodorczyk-Injeyan, J. A., Sparkes, B. G., Lalani, S., Peters, W. J., & Mills, G. B. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb05828.x · Cited by 17
Granulocyte Contamination of Ficoll-Hypaque Preparations of Mononuclear Cells following Thermal Injury May Lead to Substantial Overestimation of Lymphocyte Recovery
Calvano, S. E., Greenlee, P. G., Reid, A. M., de Riesthal, H. F., Shires, G. T., & Antonacci, A. C. (1988) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198803000-00011 · Cited by 17
Suppressor Lyt 2+ T-cells demonstrated in mice late after thermal injury
Suzuki, F., & Pollard, R. B. (1988) · Immunology Letters · doi:10.1016/0165-2478(88)90116-2 · Cited by 16
Abnormal primary antibody responses in pediatric trauma patients
Wilson, N. W., Ochs, H. D., Peterson, B., Hamburger, R. N., & Bastian, J. F. (1989) · The Journal of Pediatrics · doi:10.1016/s0022-3476(89)80846-7 · Cited by 15
Dynamics of Immunoglobulin Synthesis After Major Trauma
Ertel, W. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410120087017 · Cited by 15
Generation of functionally active suppressor cells by haemorrhage and haemorrhagic serum.
Abraham, E., & Chang, Y. (1988) · PubMed · Cited by 14
Temporal analysis of murine lymphocyte subpopulations by monoclonal antibodies and dual-color flow cytometry after burn and nonburn injury.
Hansbrough, J. F., & Ma, G. (1989) · PubMed · Cited by 14
Regulation of IgM production in thermally injured patients
Teodorczyk-Injeyan, J. A., Sparkes, B. G., & Peters, W. J. (1989) · Burns · doi:10.1016/0305-4179(89)90040-5 · Cited by 13
Actin polymerization contributes to neutrophil chemotactic dysfunction following thermal injury
Hasslen, S. R., Ahrenholz, D. H., Solem, L. D., & Nelson, R. D. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.52.5.495 · Cited by 13
The coagulum contact method (Sano) of skin grafting in the treatment of burns and wounds.
Cd, B., Gf, W., & Fp, R. (1946) · PubMed · Cited by 13
Increased Susceptibility to Infection due to Infusion of Exogenous Chemotaxin
Yurt, R. W. (1987) · Archives of Surgery · doi:10.1001/archsurg.1987.01400130117018 · Cited by 11
Chemotactic deactivation of human neutrophils: role of stimulation of hexose monophosphate shunt activity in nonspecific deactivation.
Rd, N., Fiegel, V. D., Herron, M. J., Gracyk, J., BAUMAN, M. P., Rt, M., & Simmons, R. L. (1980) · PubMed · Cited by 11
Pathophysiology of leukocyte-mediated tissue injury
Ward, P. A., Till, G. O., & Warren, J. S. (1991) · Journal of Critical Care · doi:10.1016/0883-9441(91)90016-m · Cited by 10
Density Gradient Purification of Mononuclear Cells Is Associated with Spurious (Artifactual) Immunosuppression
Xu, D.-Z., Deitch, E. A., Sittig, K. M., QI, L. U., & McDonald, J. C. (1988) · Annals of Surgery · doi:10.1097/00000658-198812000-00016 · Cited by 7
Spontaneous lymphocyte activity: an important but neglected component of the immunologic profile of the thermally injured patient.
Deitch, E. A. (1985) · PubMed · Cited by 7
Antibody formation after murine injury
Gadd, M. A., Hansbrough, J. F., Soderberg, C., & Field, T. O. (1988) · Journal of Surgical Research · doi:10.1016/0022-4804(88)90096-0 · Cited by 5
Impaired cell-mediated immunity in the first week after burn injury: investigation of spontaneous blastogenic transformation, PHA, IL-2 response and plasma suppressive activity
Zöch, G., Hamilton, G., Räth, T., Meissl, G., Kneidl, R., Roth, E., & Funovics, M. A. (1988) · Burns · doi:10.1016/s0305-4179(98)90034-1 · Cited by 5
The interaction of burn injury and zinc nutriture as assessed by the humoral response to sheep red blood cells in a burn rat model
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Suppressor T-Cell Levels are Unreliable Indicators of the Impaired Immune Response Following Thermal Injury
Gough, D. B., JORDAN, A., Collins, K., Mannick, J. A., & Rodrick, M. L. (1992) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199206000-00001 · Cited by 4

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Authors: Cioffi, W. G.
Affiliations: United States Army Institute of Surgical Research (US)
Corresponding author: Cioffi, William G.
ORCID: Cioffi, William G.
Venue: Archives of Surgery
Publisher: American Medical Association (AMA)
Published: 1993-11-01
Volume: 128
Issue: 11
Pages: 1260
ISSN: 0004-0010 (ISSN-L)
DOI: 10.1001/archsurg.1993.01420230088014
OpenAlex: W2066356532
Cited by: 71
References: 76
Citations by year: 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
FWCI: 3.57
Type: journal article
Language: en
Open access: closed
Locations: Archives of Surgery (publishedVersion)
PubMed (publishedVersion)
Defense Technical Information Center (DTIC) (submittedVersion)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: systemic inflammation, multiple organ failure, cytokines, leukocyte activation, neuroendocrine-immune interaction, coagulation, infection control, monoclonal antibodies, cytokine antagonists, host resistance
MeSH terms: Antibodies, Monoclonal, B-Lymphocytes, Blood Coagulation, Chemotaxis, Leukocyte, Complement Activation, Granulocytes, Humans, Immunity, Innate, Infections, Inflammation, Leukocytes, Multiple Organ Failure, Neurosecretory Systems, Oxidation-Reduction, T-Lymphocytes, Wounds and Injuries, Lymphocyte Subsets, Cytokines

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