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REGIONAL ILEITIS: A PATHOLOGIC AND CLINICAL ENTITY
Abstract
We propose to describe, in its pathologic and clinical details, a disease of the terminal ileum, affecting mainly young adults, characterized by a subacute or chronic necrotizing and cicatrizing inflammation. The ulceration of the mucosa is accompanied by a disproportionate connective tissue reaction of the remaining walls of the involved intestine, a process which frequently leads to stenosis of the lumen of the intestine, associated with the formation of multiple fistulas. The disease is clinically featured by symptoms that resemble those of ulcerative colitis, namely, fever, diarrhea and emaciation, leading eventually to an obstruction of the small intestine; the constant occurrence of a mass in the right iliac fossa usually requires surgical intervention (resection). The terminal ileum is alone involved. The process begins abruptly at and involves the ileocecal valve in its maximal intensity, tapering off gradually as it ascends the ileum orally for from 8 to 12 inches (20
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Cited by
Ng, S. C., Shi, H. Y., Hamidi, N., Underwood, F. E., Tang, W., Benchimol, E. I., Panaccione, R., Ghosh, S., Wu, J. C. Y., Chan, F. K. L., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32448-0 · Cited by 6,087
The global burden of IBD: from 2015 to 2025
Kaplan, G. G. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.150 · Cited by 2,639
Van Assche, G., Dignass, A., Panes, J., Beaugerie, L., Karagiannis, J., Allez, M., Ochsenkühn, T., Orchard, T., Rogler, G., Louis, E., et al. (2010) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2009.12.003 · Cited by 1,453
The four epidemiological stages in the global evolution of inflammatory bowel disease
Kaplan, G. G., & Windsor, J. W. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00360-x · Cited by 1,351
Understanding and Preventing the Global Increase of Inflammatory Bowel Disease
Kaplan, G. G., & Ng, S. C. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.020 · Cited by 1,224
Metadata
- Authors
- CROHN, B. B.
- Venue
- Journal of the American Medical Association
- Publisher
- American Medical Association (AMA)
- Published
- 1932-10-15
- Volume
- 99
- Issue
- 16
- Pages
- 1323
- ISSN
- 0002-9955 (ISSN-L)
- OpenAlex
- W2059904611
- Cited by
- 1,512
- References
- 0
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CROHN, B. B. (1932). REGIONAL ILEITIS: A PATHOLOGIC AND CLINICAL ENTITY. Journal of the American Medical Association. https://doi.org/10.1001/jama.1932.02740680019005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
